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Development of High Density MoO3 Pellets for Production of 99Mo Medical Isotope
This content has been downloaded from IOPscience. Please scroll down to see the full text. 2011 IOP Conf. Ser.: Mater. Sci. Eng. 18 042001 (http://iopscience.iop.org/1757-899X/18/4/042001) View the table of contents for this issue, or go to the journal homepage for more
Download details: IP Address: 198.189.249.60 This content was downloaded on 11/11/2014 at 23:07
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ICC3: Symposium 2B: Novel Chemical Processing IOP Conf. Series: Materials Science and Engineering 18 (2011) 042001
IOP Publishing doi:10.1088/1757-899X/18/4/042001
Development of High Density MoO3 Pellets for Production of Mo Medical Isotope
99
A. Kimura 1,*, Y.Sato 2, M.Tanase 2, K. Tsuchiya 1 1 Neutron Irradiation and Testing Reactor Center, Japan Atomic Energy Agency 4002 Narita-cho, Oarai-machi, Higashiibaraki-gun, Ibaraki-ken 311-1393, Japan 2 Chiyoda Technol Corporation 3681, Narita-cho, Oarai-machi, Higashiibaraki-gun, Ibaraki-ken, 311-1313, Japan E-mail: [email protected] Abstract. 99mTc is the most widely used radioisotope in diagnostic radiopharmanceuticals. However, the supply of 99Mo, the parent nuclide of 99mTc, in Japan depends entirely on the import from foreign countries. Thus, it is necessary to supply 99Mo stably by the domestic production, because of the unplanned shutdown and aged state of the foreign countries’ reactors for 99Mo production. Japan Atomic Energy Agency (JAEA) has a plan to produce 99 Mo. It is necessary that increasing of target volume for supplying 99Mo stably. Pellets as irradiation target was studied. It is difficult to produce the pellets with high density, because MoO3 sublimes at low temperature. In this study, MoO3 pellets were produced by two kinds of production methods and characterization of these pellets were carried out. MoO3 pellets were produced by the cold pressing sintering (CIP) method at first. Next, MoO3 pellets were produced by the Spark Plasma Sintering (SPS) method. As a result, high density MoO3 pellets were produced by the SPS method and the characteristics of the MoO3 pellets were confirmed.
1. Introduction Radiaoisotope productions such as 99Mo and 192Ir have been planned after the refurbishment of Japan Materials Testing Reactor (JMTR) as a part of the industrial use expansion [1-2]. Technetium-99m (99mTc, t1/2=6.01h) is the most widely used radioisotope in diagnostic radiopharmanceuticals. 99mTc is obtained repeatedly every day from 99Mo-99mTc equilibrium where 99 Mo decays by - emission with a half life of 66h to 99mTc [3]. However, the supply of 99Mo in Japan depends entirely on the import from foreign countries. Thus, it is necessary to supply 99Mo stably by the domestic production, because of the unplanned shutdown and aged state of the foreign countries’ reactors for 99Mo production [4]. There are two kinds of production methods of 99Mo; one is the nuclear fission (n, f) method [5] and the other is the neutron capture (n, γ) method. Production of 99Mo by (n, f) method needs high cost and it is troublesome to handle Uranium [6]. On the other hand, the production of 99Mo by (n, γ) method will be carried out at low cost and the target containing Mo can be handled easily. Thus, (n, γ)
c 2011 Ceramic Society of Japan.
1
Published under licence by IOP Publishing Ltd
ICC3: Symposium 2B: Novel Chemical Processing IOP Conf. Series: Materials Science and Engineering 18 (2011) 042001
IOP Publishing doi:10.1088/1757-899X/18/4/042001
method as the 99Mo production is selected in JMTR and it should be necessary to develop the irradiation targets of molybdenum compounds. In this study, productions of high-density MoO3 pellets were tried by the Cold Isostatic Press (CIP) method and the Spark Plasma Sintering (SPS) method. The characteristics of these produced MoO3 pellets were examined and two kinds of the production methods compared. 2. Production of MoO3 pellets 2-1. CIP method MoO3 pellets were produced by the CIP method [7]. Production flow by CIP method is shown in Figure 1. MoO3 powder and poly vinyl alcohol (PVA) are mixed. The purity of MoO3 powder was 99.9% and the main impurities of MoO3 powder were as follows: Fe, 10; Cu, 2; Na, 9; SO4,
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My IOPscience
Development of High Density MoO3 Pellets for Production of 99Mo Medical Isotope
This content has been downloaded from IOPscience. Please scroll down to see the full text. 2011 IOP Conf. Ser.: Mater. Sci. Eng. 18 042001 (http://iopscience.iop.org/1757-899X/18/4/042001) View the table of contents for this issue, or go to the journal homepage for more
Download details: IP Address: 198.189.249.60 This content was downloaded on 11/11/2014 at 23:07
Please note that terms and conditions apply.
ICC3: Symposium 2B: Novel Chemical Processing IOP Conf. Series: Materials Science and Engineering 18 (2011) 042001
IOP Publishing doi:10.1088/1757-899X/18/4/042001
Development of High Density MoO3 Pellets for Production of Mo Medical Isotope
99
A. Kimura 1,*, Y.Sato 2, M.Tanase 2, K. Tsuchiya 1 1 Neutron Irradiation and Testing Reactor Center, Japan Atomic Energy Agency 4002 Narita-cho, Oarai-machi, Higashiibaraki-gun, Ibaraki-ken 311-1393, Japan 2 Chiyoda Technol Corporation 3681, Narita-cho, Oarai-machi, Higashiibaraki-gun, Ibaraki-ken, 311-1313, Japan E-mail: [email protected] Abstract. 99mTc is the most widely used radioisotope in diagnostic radiopharmanceuticals. However, the supply of 99Mo, the parent nuclide of 99mTc, in Japan depends entirely on the import from foreign countries. Thus, it is necessary to supply 99Mo stably by the domestic production, because of the unplanned shutdown and aged state of the foreign countries’ reactors for 99Mo production. Japan Atomic Energy Agency (JAEA) has a plan to produce 99 Mo. It is necessary that increasing of target volume for supplying 99Mo stably. Pellets as irradiation target was studied. It is difficult to produce the pellets with high density, because MoO3 sublimes at low temperature. In this study, MoO3 pellets were produced by two kinds of production methods and characterization of these pellets were carried out. MoO3 pellets were produced by the cold pressing sintering (CIP) method at first. Next, MoO3 pellets were produced by the Spark Plasma Sintering (SPS) method. As a result, high density MoO3 pellets were produced by the SPS method and the characteristics of the MoO3 pellets were confirmed.
1. Introduction Radiaoisotope productions such as 99Mo and 192Ir have been planned after the refurbishment of Japan Materials Testing Reactor (JMTR) as a part of the industrial use expansion [1-2]. Technetium-99m (99mTc, t1/2=6.01h) is the most widely used radioisotope in diagnostic radiopharmanceuticals. 99mTc is obtained repeatedly every day from 99Mo-99mTc equilibrium where 99 Mo decays by - emission with a half life of 66h to 99mTc [3]. However, the supply of 99Mo in Japan depends entirely on the import from foreign countries. Thus, it is necessary to supply 99Mo stably by the domestic production, because of the unplanned shutdown and aged state of the foreign countries’ reactors for 99Mo production [4]. There are two kinds of production methods of 99Mo; one is the nuclear fission (n, f) method [5] and the other is the neutron capture (n, γ) method. Production of 99Mo by (n, f) method needs high cost and it is troublesome to handle Uranium [6]. On the other hand, the production of 99Mo by (n, γ) method will be carried out at low cost and the target containing Mo can be handled easily. Thus, (n, γ)
c 2011 Ceramic Society of Japan.
1
Published under licence by IOP Publishing Ltd
ICC3: Symposium 2B: Novel Chemical Processing IOP Conf. Series: Materials Science and Engineering 18 (2011) 042001
IOP Publishing doi:10.1088/1757-899X/18/4/042001
method as the 99Mo production is selected in JMTR and it should be necessary to develop the irradiation targets of molybdenum compounds. In this study, productions of high-density MoO3 pellets were tried by the Cold Isostatic Press (CIP) method and the Spark Plasma Sintering (SPS) method. The characteristics of these produced MoO3 pellets were examined and two kinds of the production methods compared. 2. Production of MoO3 pellets 2-1. CIP method MoO3 pellets were produced by the CIP method [7]. Production flow by CIP method is shown in Figure 1. MoO3 powder and poly vinyl alcohol (PVA) are mixed. The purity of MoO3 powder was 99.9% and the main impurities of MoO3 powder were as follows: Fe, 10; Cu, 2; Na, 9; SO4,
