Skin Research and Technology 2015; 21: 15–17 Printed in Singapore  All rights reserved doi: 10.1111/srt.12149

© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Skin Research and Technology

Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report S. A. Alawi1, S. Batz1, J. R€ owert-Huber1, J. W. Fluhr1, J. Lademann1 and M. Ulrich2 1

Department of Dermatology, Venereology and Allergology, Skin Cancer Centre Charite, Charite – Universit€atsmedizin Berlin,Berlin, Germany and 2 Dermatologie am Regierungsviertel, Berlin, Germany

Background/Aims: Herein, we report a case of microcystic adnexal carcinoma (MAC), which we correlated and evaluated by optical coherence tomography (OCT) and conventional H&E histology. Methods: A commercially available OCT scanner was used for imaging. Several multi-slice images were obtained from the central portion of the lesion. Correlation of OCT findings with histology was performed retrospectively. Results: Microcystic adnexal carcinoma showed characteristic criteria, which were divided into superficial and sub-epidermal findings.

Conclusion: The use of OCT can visualize characteristic criteria of MAC, thus enabling prompt diagnosis before surgery.

is a noninvasive, real-time, cross-sectional technique. Due to the non-invasiveness, OCT may be useable for diagnosis and in particular for therapeutic monitoring and marginal mapping of skin cancer in vivo (1). Microcystic adnexal carcinoma (MAC) represents a rare type of malignant sweat gland neoplasm. MAC clinically presents as a nodule or plaque-like lesion commonly located in the head and neck region with local aggressive and invasive tumor growth. Goldstein et al. described MAC 1982 by the histological features of abortive follicles in upper dermis surrounded by desmoplastic stroma and islands and strands of small basaloid, benignappearing keratinocytes or squamous cells, which do not present cytologic atypia and mitotic figures, and areas of ductal differentiation (2). In addition, the dermis shows increased ductal structures (3). Recommended treatment includes wide local resection. Those resections can be more controlled due to the non-invasive quality of optical coherence tomography (OCT). To our knowledge, this is the first report on OCT criteria of microcystic adnexal carcinoma.

Case report

O

PTICAL COHERENCE TOMOGRAPHY

Key words: optical coherence tomography – diagnosis – Mohs surgery – non-melanoma skin cancer – microcystic adnexal carcinoma

Ó 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Accepted for publication 5 January 2014

An 81-year-old patient scheduled for dermatologic surgery at the Charite- Universit€atsmedizin Berlin presented a 1 9 2 cm tumor recurrence of a previously diagnosed MAC on her left cheek. OCT analysis was performed prior to surgery. A commercially available OCT device was used for imaging (VivoSight, Michelson Diagnostics, Kent, UK). The axial optical resolution in tissue is

Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report.

Herein, we report a case of microcystic adnexal carcinoma (MAC), which we correlated and evaluated by optical coherence tomography (OCT) and conventio...
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