Original Article

Correlation in histological subtypes with high resolution computed tomography signatures of early stage lung adenocarcinoma Yingying Miao1,2*, Jianya Zhang1,2*, Jiawei Zou1,2, Qingqing Zhu1,2, Tangfeng Lv1,2, Yong Song1,2 1

Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medical, Nanjing 210002, China; 2Nanjing University

Institute of Respiratory Medicine, Nanjing 210002, China Contributions: (I) Conception and design: T Lv, Y Miao; (II) Administrative support: J Zhang; (III) Provision of study materials or patients: T Lv, Y Song; (IV) Collection and assembly of data: Y Miao, J Zou; (V) Data analysis and interpretation: Y Miao, J Zhang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. *These authors contributed equally to this work. Correspondence to: Tangfeng Lv, MD, PhD; Yong Song, MD, PhD. Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing University Institute of Respiratory Medicine, 305 East Zhongshan Road, Nanjing 210002, China. Email: [email protected]; [email protected].

Background: Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopathologic subtypes. We aimed to estimate the correlation between preoperative high resolution computed tomography (HRCT) scan and postoperative histopathology of stage IA lung adenocarcinoma in East Asian Chinese population. Methods: We retrospectively reviewed the clinical records and HRCT images of 190 patients (106 female and 84 male) with resected, preoperatively untreated stage IA adenocarcinomas. The relationship between image characteristics of nodules at preoperative HRCT and their histological subtypes after resection were analyzed. The one-way ANOVA, chi-square test and logistic regression were used for analysis. Results: In 190 patients with stage IA lung adenocarcinoma, median tumor diameter was significantly lower in lepidic predominant invasive adenocarcinoma (LPA) (15.96±6.95 mm). Univariate analysis revealed that ground-glass opacity (GGO) proportion (P

Correlation in histological subtypes with high resolution computed tomography signatures of early stage lung adenocarcinoma.

Uncertainty remains on the association between image characteristics of the nodules in computed tomography (CT) scans and lung adenocarcinoma histopat...
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