Original Article

Correlation between serum neuron specific enolase and functional neurological outcome in patients of acute ischemic stroke Sana Zaheer, Mujahid Beg, Imran Rizvi, Najmul Islam1, Ekram Ullah2, Nishat Akhtar3 Departments of Medicine, 1Biochemistry, 2Radio Diagnosis and 3Obstetrics and Gynecology, J N Medical College, Aligarh, Uttar Pradesh, India Abstract Context: The use of biomarkers to predict stroke prognosis is gaining particular attention nowadays. Neuron specific enolase (NSE), which is a dimeric isoenzyme of the glycolytic enzyme enolase and is found mainly in the neurons is one such biomarker. Aims: This study was carried out on patients of acute ischemic stroke with the aims to determine the correlation between NSE levels on the day of admission with infarct volume, stroke severity, and functional neurological outcome on day 30. Materials and Methods: Seventy five patients of acute ischemic stroke admitted in the Department of Medicine were included in the study. Levels of NSE were determined on day 1 using the human NSE ELISA kit (Alpha Diagnostic International Texas 78244, USA). Volume of infarct was measured by computed tomography (CT) scan using the preinstalled software Syngo (version A40A) of Siemen’s medical solutions (Forchheim, Germany). Stroke severity at admission was assessed using Glasgow coma scale (GCS) and functional neurological outcome was assessed using modified Rankin scale (mRS) on day 30. Statistical Analysis Used: Statistical analysis was performed using the SPSS software for windows version 15.0 (SPSS). Results: A positive correlation was found between concentration of NSE on day 1 and infarct volume determined by CT scan (r = 0.955, P 

Correlation between serum neuron specific enolase and functional neurological outcome in patients of acute ischemic stroke.

The use of biomarkers to predict stroke prognosis is gaining particular attention nowadays. Neuron specific enolase (NSE), which is a dimeric isoenzym...
1MB Sizes 3 Downloads 0 Views

Recommend Documents


Is there a correlation between socioeconomic disparity and functional outcome after acute ischemic stroke?
To investigate the impact of low socioeconomic status (SES), indicated by low level of education, occupation and income, on 3 months functional outcome after ischemic stroke.

Serum neuron-specific enolase predicting neurological outcomes post-cardiac arrest: a review of the literature.
Coronary artery disease is a major problem in the United States, affecting 785 000 individuals, with the most serious event being a cardiopulmonary arrest. Families of post-cardiac arrest patients are left with difficult decisions to be made.

Serum copeptin and neuron specific enolase are markers of neonatal distress and long-term neurodevelopmental outcome.
The objective of this study was to evaluate the early changes in serial serum levels of copeptin and neuron-specific enolase (NSE) in neonates diagnosed with birth asphyxia, and to determine whether these biomarkers measured in the first 168 hours af

Timing of neurological improvement after acute ischemic stroke and functional outcome.
The time of neurological improvement (TNI) after acute ischemic stroke may have a predictive value.

The second elevation of neuron-specific enolase peak after ischemic stroke is associated with hemorrhagic transformation.
Neuron-specific enolase (NSE) is a surrogate marker for the extent of brain damage after ischemic stroke and affords a good predictor of stroke prognosis. We hypothesized that the pattern of NSE level changes in the peripheral blood during the acute

Serum neuron specific enolase - impact of storage and measuring method.
Neuron specific enolase (NSE) is a recognized biomarker for assessment of neurological outcome after cardiac arrest, but its reliability has been questioned. Our aim was to investigate what influence storage of samples and choice of measuring methods

Early neurological stability predicts adverse outcome after acute ischemic stroke.
Background Deterioration in the National Institutes of Health Stroke Scale (NIHSS) in the early days after stroke is associated with progressive infarction, brain edema, and/or hemorrhage, leading to worse outcome. Aims We sought to determine whether

Redox status in acute ischemic stroke: correlation with clinical outcome.
Connection between oxidative stress and clinical outcome in acute ischemic stroke (AIS) has been poorly investigated. This study was aimed to assess redox state (through measurement of oxidative stress markers) of patients with acute ischemic stroke

Is there a correlation between hs-CRP levels and functional outcome of Ischemic Stroke?
C-reactive protein, a well known marker of inflammation is being investigated as a probable marker of predicting acute cardiovascular events and its severity. The aim of the present study was to assess the possible role of highly-sensitivity C-reacti

Arterial stiffness and functional outcome in acute ischemic stroke.
Arterial stiffness is a common change associated with aging and can be evaluated by measuring pulse wave velocity (PWV) between sites in the arterial tree, with the stiffer artery having the higher PWV. Arterial stiffness is associated with the risk