Copper-catalyzed trifluoromethylation of alkenes with an electrophilic trifluoromethylating reagent.

An efficient method for the copper-catalyzed trifluoromethylation of terminal alkenes with an electrophilic trifluoromethylating reagent has been deve...
293KB Sizes 0 Downloads 0 Views

Recommend Documents

Recent advances in trifluoromethylation reactions with electrophilic trifluoromethylating reagents.
Electrophilic trifluoromethylation reactions have been the latest approach to achieve the fluoroalkylation of compounds with newly-discovered reagents, such as the Togni's (1-trifluoromethyl-1,2-benziodoxol-3-(1 H)-one), Umemoto's (S-(trifluoromethyl

Silver-catalyzed C-H trifluoromethylation of arenes using trifluoroacetic acid as the trifluoromethylating reagent.
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove

Synthesis of α-trifluoromethyl ketones via the Cu-catalyzed trifluoromethylation of silyl enol ethers using an electrophilic trifluoromethylating agent.
A method has been developed for the synthesis of α-trifluoromethyl ketones via the Cu-catalyzed trifluoromethylation of silyl enol ethers with an electrophilic trifluoromethylating agent, which produces a trifluoromethyl radical.

Metal-free direct trifluoromethylation of activated alkenes with Langlois' reagent leading to CF3-containing oxindoles.
A metal-free and cost-effective synthesis protocol has been initially proposed for the construction of CF3-containing oxindoles via the direct oxidative trifluoromethylation of activated alkenes with Langlois' reagent (CF3SO2Na). The present methodol

Trifluoromethylation of alkenes with concomitant introduction of additional functional groups.
The trifluoromethyl group is found in many synthetic bioactive compounds, and the difunctionalization of a C=C bond, as a powerful strategy for the construction of compounds with various functional groups, has been intensively investigated. Therefore

Copper(I)-photocatalyzed trifluoromethylation of alkenes.
Using the photoreducible Cu(II) precatalyst 2, trifluoromethylation reactions of alkenes are conducted effectively at low copper loading (0.1-0.5 mol%) on exposing the reaction mixture to sunlight/ambient light.

Introducing a new radical trifluoromethylation reagent.
Perfluoro-3-ethyl-2,4-dimethyl-3-pentyl radical (PPFR) is a persistent radical stable at room temperature, but easily decomposes at 90 °C to produce a CF3 radical which is able to react with a variety of aromatic compounds to afford the corresponding

Product Control in Alkene Trifluoromethylation: Hydrotrifluoromethylation, Vinylic Trifluoromethylation, and Iodotrifluoromethylation using Togni Reagent.
Hydrotrifluoromethylation, vinylic trifluoromethylation, and iodotrifluoromethylation of simple alkenes have been achieved by using Togni reagent in the absence of any transition metal catalyst. These reactions were readily controllable by selection

Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines.
A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through tandem C-O and C-CF3 bond f