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JNNP Online First, published on November 18, 2013 as 10.1136/jnnp-2013-305323 Movement disorders
RESEARCH PAPER
Controlled general anaesthesia for subthalamic nucleus stimulation in Parkinson’s disease F Fluchere,1 T Witjas,1,2 A Eusebio,1,2 N Bruder,3 R Giorgi,4 M Leveque,5 J-C Peragut,5 J-P Azulay,1,2 J Regis5 1
Department of Neurology and Movement Disorders, APHM, La Timone, Pôle de Neurosciences cliniques, Aix-Marseille Univ, Marseille, Cedex, France 2 Institut de Neurosciences de la Timone UMR 7289 Aix Marseille Univ, CNRS, Marseille, Cedex, France 3 Department of Anesthesiology, APHM, La Timone, Aix-Marseille Univ, Marseille, Cedex, France 4 Service de Santé Publique et d’Information Médicale and LERTIM, APHM, La Timone, Aix-Marseille Univ, Marseille, Cedex, France 5 Department of Stereotactic and Functional Neurosurgery, APHM, La Timone, Pôle de Neurosciences cliniques, Aix-Marseille Univ, Marseille, Cedex, France Correspondence to Dr Frederique Fluchere, Department of Neurology and Movement Disorders, APHM, La Timone, Pôle de Neurosciences cliniques, 13385 Marseille, Aix-Marseille Univ, Cedex 05, France; frederique.fl[email protected] Received 12 May 2013 Revised 25 September 2013 Accepted 21 October 2013
ABSTRACT Objective To report the short-term (1 year) and longterm (5 years) outcome of patients with Parkinson’s disease (PD) with subthalamic nucleus (STN) stimulation operated upon under controlled general anaesthesia (GA). Methods 213 consecutive patients with PD were included between January 2000 and March 2009 and operated upon under a particular type of GA with close control of the level of sedation allowing intraoperative recordings. 188 patients were assessed 1 year postoperatively. 65 patients also completed the longterm observation period and were evaluated 5 years postoperatively. Results The Unified PD Rating Scale III score in the ‘Off drug—On stim’ condition was improved at 1 year and 5 years by 61% and 37%, respectively, ( p
JNNP Online First, published on November 18, 2013 as 10.1136/jnnp-2013-305323 Movement disorders
RESEARCH PAPER
Controlled general anaesthesia for subthalamic nucleus stimulation in Parkinson’s disease F Fluchere,1 T Witjas,1,2 A Eusebio,1,2 N Bruder,3 R Giorgi,4 M Leveque,5 J-C Peragut,5 J-P Azulay,1,2 J Regis5 1
Department of Neurology and Movement Disorders, APHM, La Timone, Pôle de Neurosciences cliniques, Aix-Marseille Univ, Marseille, Cedex, France 2 Institut de Neurosciences de la Timone UMR 7289 Aix Marseille Univ, CNRS, Marseille, Cedex, France 3 Department of Anesthesiology, APHM, La Timone, Aix-Marseille Univ, Marseille, Cedex, France 4 Service de Santé Publique et d’Information Médicale and LERTIM, APHM, La Timone, Aix-Marseille Univ, Marseille, Cedex, France 5 Department of Stereotactic and Functional Neurosurgery, APHM, La Timone, Pôle de Neurosciences cliniques, Aix-Marseille Univ, Marseille, Cedex, France Correspondence to Dr Frederique Fluchere, Department of Neurology and Movement Disorders, APHM, La Timone, Pôle de Neurosciences cliniques, 13385 Marseille, Aix-Marseille Univ, Cedex 05, France; frederique.fl[email protected] Received 12 May 2013 Revised 25 September 2013 Accepted 21 October 2013
ABSTRACT Objective To report the short-term (1 year) and longterm (5 years) outcome of patients with Parkinson’s disease (PD) with subthalamic nucleus (STN) stimulation operated upon under controlled general anaesthesia (GA). Methods 213 consecutive patients with PD were included between January 2000 and March 2009 and operated upon under a particular type of GA with close control of the level of sedation allowing intraoperative recordings. 188 patients were assessed 1 year postoperatively. 65 patients also completed the longterm observation period and were evaluated 5 years postoperatively. Results The Unified PD Rating Scale III score in the ‘Off drug—On stim’ condition was improved at 1 year and 5 years by 61% and 37%, respectively, ( p
