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International Journal of Preventive Medicine Letter to Editor
Open Access
Control or Placebo Group in A Clinical Trial Mohammad Saeid Rezaee‑Zavareh Student’s Research Committee, Baqiatallah university of Medical Sciences, Tehran, IR Iran
Correspondence to: Dr. Mohammad Saeid Rezaee‑Zavareh, Baqiyatallah University of Medical Sciences, Tehran, IR Iran. E‑mail: [email protected] How to cite this article: Rezaee-Zavareh MS. Control or Placebo Group in A Clinical Trial. Int J Prev Med 2015;6:19.
DEAR EDITOR, I read the important article written by Delui et al. entitled “The Effects of Panax ginseng on Lipid Profile, Pro‑oxidant: Antioxidant Status and High‑sensitivity C Reactive Protein Levels in Hyperlipidemic Patients in Iran”[1] recently published in your journal. Effect of P. ginseng on lipid profile has been investigated in some studies in both animal and human models.[2,3] In this article, the authors skilfully have showed that P. ginseng does not have a meaningful impact on lipid profile, and they have suggested more studies in this field. In the abstract of this paper, it is said that patients (40) were randomly assigned to placebo (20) and control (20) groups and based on the method part of this article, it is understood that 20 patients have taken placebo and the rest have taken ginseng. However in the clinical trials, placebo group is usually used as a control group for comparing with other groups in the study so that the authors can relate the results of the study to the one factor (medicine). Hence, it can be said the control and placebo groups are same and therefore there is a typesetting or other types of error in the Hassanzadeh et al.’s study.
In the end, I would like to thank authors for running such a precise randomized controlled trial. Received: 29 Oct 14 Accepted: 12 Nov 14 Published: 03 Mar 15
REFERENCES 1.
2. 3.
Delui MH, Fatehi H, Manavifar M, Amini M, Ghayour‑Mobarhan M, Zahedi M, et al. The effects of Panax ginseng on lipid profile, pro‑oxidant: Antioxidant status and high‑sensitivity c reactive protein levels in hyperlipidemic patients in Iran. Int J Prev Med 2013;4:1045‑51. Kim SH, Park KS. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacol Res 2003;48:511‑3. Lee LS, Cho CW, Hong HD, Lee YC, Choi UK, Kim YC. Hypolipidemic and antioxidant properties of phenolic compound‑rich extracts from white ginseng (Panax ginseng) in cholesterol‑fed rabbits. Molecules 2013;18:12548‑60.
Access this article online Quick Response Code: Website: www.ijpvmjournal.net / www.ijpm.ir
DOI: 10.4103/2008-7802.152495
Copyright: © 2015 Rezaee‑Zavareh MS. This is an open‑access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright of International Journal of Preventive Medicine is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
International Journal of Preventive Medicine Letter to Editor
Open Access
Control or Placebo Group in A Clinical Trial Mohammad Saeid Rezaee‑Zavareh Student’s Research Committee, Baqiatallah university of Medical Sciences, Tehran, IR Iran
Correspondence to: Dr. Mohammad Saeid Rezaee‑Zavareh, Baqiyatallah University of Medical Sciences, Tehran, IR Iran. E‑mail: [email protected] How to cite this article: Rezaee-Zavareh MS. Control or Placebo Group in A Clinical Trial. Int J Prev Med 2015;6:19.
DEAR EDITOR, I read the important article written by Delui et al. entitled “The Effects of Panax ginseng on Lipid Profile, Pro‑oxidant: Antioxidant Status and High‑sensitivity C Reactive Protein Levels in Hyperlipidemic Patients in Iran”[1] recently published in your journal. Effect of P. ginseng on lipid profile has been investigated in some studies in both animal and human models.[2,3] In this article, the authors skilfully have showed that P. ginseng does not have a meaningful impact on lipid profile, and they have suggested more studies in this field. In the abstract of this paper, it is said that patients (40) were randomly assigned to placebo (20) and control (20) groups and based on the method part of this article, it is understood that 20 patients have taken placebo and the rest have taken ginseng. However in the clinical trials, placebo group is usually used as a control group for comparing with other groups in the study so that the authors can relate the results of the study to the one factor (medicine). Hence, it can be said the control and placebo groups are same and therefore there is a typesetting or other types of error in the Hassanzadeh et al.’s study.
In the end, I would like to thank authors for running such a precise randomized controlled trial. Received: 29 Oct 14 Accepted: 12 Nov 14 Published: 03 Mar 15
REFERENCES 1.
2. 3.
Delui MH, Fatehi H, Manavifar M, Amini M, Ghayour‑Mobarhan M, Zahedi M, et al. The effects of Panax ginseng on lipid profile, pro‑oxidant: Antioxidant status and high‑sensitivity c reactive protein levels in hyperlipidemic patients in Iran. Int J Prev Med 2013;4:1045‑51. Kim SH, Park KS. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacol Res 2003;48:511‑3. Lee LS, Cho CW, Hong HD, Lee YC, Choi UK, Kim YC. Hypolipidemic and antioxidant properties of phenolic compound‑rich extracts from white ginseng (Panax ginseng) in cholesterol‑fed rabbits. Molecules 2013;18:12548‑60.
Access this article online Quick Response Code: Website: www.ijpvmjournal.net / www.ijpm.ir
DOI: 10.4103/2008-7802.152495
Copyright: © 2015 Rezaee‑Zavareh MS. This is an open‑access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright of International Journal of Preventive Medicine is the property of Medknow Publications & Media Pvt. Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
