Contributing Factors for Development of Necrotizing Enterocolitis
DOI: 10.5455/msm.2016.53-56
Published online:30/01/2016
Published print:02/2016
Received: 10 October 2015; Accepted: 25 December 2015 © 2016 Zlatan Zvizdic, Suada Heljic, Nusret Popovic, Jasmina Alajbegovic-Halimic, Emir Milisic, Asmir Jonuzi This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ORIGINAL PAPER
Mater Sociomed. 2016 Feb; 28(1): 53-56
CONTRIBUTING FACTORS FOR DEVELOPMENT OF NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS IN THE NEONATAL INTENSIVE CARE UNIT Zlatan Zvizdic1, Suada Heljic2, Nusret Popovic1, Jasmina Alajbegovic-Halimic3, Emir Milisic1, Asmir Jonuzi Clinic of Pediatric Surgery, University Clinical Center, Sarajevo, Sarajevo, Bosnia and Herzegovina Pediatric Clinic, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina 3 Eye Clinic, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina 1
2
Corresponding author: Zlatan Zvizdic, MD; PhD; Clinic of Pediatric Surgery, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina. Phone: +387 61 194 924; E-mail:[email protected] ABSTRACT Background: necrotizing enterocolitis is a serious condition that affects mostly preterm infants, with high mortality rate. Aim: to estimate the influence of potentially contributing factors of this multifactorial disease. Methods: the study group included 51 necrotizing enterocolitis infants who were less than 37 week gestation who were hospitalized in NICU during a five year period. The control group consisted of 71 patients with approximately the same gestational age and birth weight. Average gestational age in the study group was 30.2 weeks (SD 3.7), average birth weight 1502g (SD 781.5). Average postnatal age in the time of the presenting NEC was 18.2 days (SD 12.8). Results: Logistic regression estimates the influence of risk factors, which in our study related to the treatment of preterm infants on the likelihood of NEC development. Our regression model consisted of seven independent variables (nosocomial infections, mechanical ventilation, nasal continuous positive pressure, morphine, inotropes, blood transfusions, and H2 blockers), which were shown to have a statistically significant impact, X2 (7, n=1222) = 49.522, p
DOI: 10.5455/msm.2016.53-56
Published online:30/01/2016
Published print:02/2016
Received: 10 October 2015; Accepted: 25 December 2015 © 2016 Zlatan Zvizdic, Suada Heljic, Nusret Popovic, Jasmina Alajbegovic-Halimic, Emir Milisic, Asmir Jonuzi This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ORIGINAL PAPER
Mater Sociomed. 2016 Feb; 28(1): 53-56
CONTRIBUTING FACTORS FOR DEVELOPMENT OF NECROTIZING ENTEROCOLITIS IN PRETERM INFANTS IN THE NEONATAL INTENSIVE CARE UNIT Zlatan Zvizdic1, Suada Heljic2, Nusret Popovic1, Jasmina Alajbegovic-Halimic3, Emir Milisic1, Asmir Jonuzi Clinic of Pediatric Surgery, University Clinical Center, Sarajevo, Sarajevo, Bosnia and Herzegovina Pediatric Clinic, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina 3 Eye Clinic, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina 1
2
Corresponding author: Zlatan Zvizdic, MD; PhD; Clinic of Pediatric Surgery, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina. Phone: +387 61 194 924; E-mail:[email protected] ABSTRACT Background: necrotizing enterocolitis is a serious condition that affects mostly preterm infants, with high mortality rate. Aim: to estimate the influence of potentially contributing factors of this multifactorial disease. Methods: the study group included 51 necrotizing enterocolitis infants who were less than 37 week gestation who were hospitalized in NICU during a five year period. The control group consisted of 71 patients with approximately the same gestational age and birth weight. Average gestational age in the study group was 30.2 weeks (SD 3.7), average birth weight 1502g (SD 781.5). Average postnatal age in the time of the presenting NEC was 18.2 days (SD 12.8). Results: Logistic regression estimates the influence of risk factors, which in our study related to the treatment of preterm infants on the likelihood of NEC development. Our regression model consisted of seven independent variables (nosocomial infections, mechanical ventilation, nasal continuous positive pressure, morphine, inotropes, blood transfusions, and H2 blockers), which were shown to have a statistically significant impact, X2 (7, n=1222) = 49.522, p
