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Continuing Medical Education: September 2014 Continuing Medical Education: Opioid-Induced Constipation Annenberg Center for Health Sciences at Eisenhower designates this enduring material for a maximum of 6.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Successful completion of this enduring material is achieved by reading the material, reflecting on its implications in your practice, and completing the assessment component. The estimated time to complete the activity is 6 h. Release date: 8 September 2014

Expiration date: 8 September 2015

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© 2014 Nature America, Inc. All rights reserved.

Am J Gastroenterol Suppl 2014; 2:1; doi:10.1038/ajgsup.2014.1

Target audience This activity is designed for physicians focusing on gastroenterology and others who treat patients with opioid-induced constipation, including physician assistants, nurse practitioners, and other advanced practice health-care professionals. Learning objectives After reading the articles in this supplement, which focuses primarily on the diagnosis and contemporary treatment of opioid-induced constipation, the reader should appreciate the prevalence and impact of opioid-induced constipation, and understand the efficacy and safety of currently available therapies for this common consequence of opioid treatment. More specifically, the reader should be able to:

• • • •



Describe the physiology of opioid receptors. Identify the physiologic mechanisms underlying both the efficacy of opioid treatments and their gastroenterologic side effects. Discuss the efficacy and safety of current pharmacologic and nonpharmacologic modalities for the management of opioid-induced constipation. Formulate an appropriate treatment plan for patients with opioid-induced constipation that balances the need for analgesic efficacy with their propensity to cause constipation. Recognize narcotic bowel syndrome and describe its treatment.

Disclosure of conflict of interest

All faculty and staff involved in the planning or presentation of continuing education activities sponsored/provided by Annenberg Center for Health Sciences at Eisenhower (ACHS) are required to disclose to the audience any real or apparent commercial financial affiliations related to the content of the presentation or enduring material. Full disclosure of all commercial relationships must be made in writing to the audience prior to the activity. Charles Willis, Director of Continuing Education (ACHS), consults for Pfizer Inc.; all other staff at the Annenberg Center for Health Sciences at Eisenhower and The Gi Health Foundation has no relationships to disclose.

© 2014 by the American College of Gastroenterology

Learner Assurance Statement The Annenberg Center for Health Sciences at Eisenhower is committed to resolving all conflict of interest issues that could arise as a result of prospective faculty members’ significant relationships with drug or device manufacturer(s). The Annenberg Center for Health Sciences at Eisenhower is committed to retaining only those speakers with financial interests that can be reconciled with the goals and educational integrity of the CME activity. Physician Disclosure Statement Faculty members are required to inform the audience when they are discussing off-label, unapproved uses of devices and drugs. Physicians should consult full prescribing information before using any product mentioned during this educational activity. The opinions expressed during the enduring activity are those of the faculty and do not necessarily represent the views of the Annenberg Center for Health Sciences at Eisenhower. The information is presented for the purpose of advancing the attendees’ professional development. Instructions on participation and receiving credit: There are no fees for participating in or receiving credit for this educational activity. For information on applicability and acceptance of continuing medical education credit for this activity, please consult your professional licensing board. This activity is designed to be completed within 6 h; physicians should claim only those credits that reflect the time actually spent in the activity. To successfully earn credit, participants must complete the activity online during the valid period. One year from the release date, tests will expire and credit will no longer be offered.

Follow these steps to earn AMA PRA Category 1 Credit™: 1. Read the target audience, learning objectives, and author disclosures. 2. Read the article in print or online format. 3. Reflect on the article. 4. Access the CME Exam for the article online http://www.gihealth foundation.org/oicCMEsupplement and choose the best answer to each test question. 5. All questions must be answered correctly to obtain credit. 6. Complete the required evaluation component of the online activity and the required fields for the creation of your CME certificate. If you have any questions or concerns regarding this activity, please contact the Gi Health Foundation at 877-782-4532 or [email protected]

The American Journal of GASTROENTEROLOGY Supplements

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Continuing medical education: september 2014.

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