Accepted Manuscript Confocal Microscopy Analysis of Corneal Changes after Photorefractive Keratectomy Plus Cross-Linking for Keratoconus: 4-Year Follow-Up Giovanni Alessio , MD Milena L’abbate , MD Claudio Furino , MD Carlo Sborgia , MD Maria Gabriella La Tegola , MD PII:
S0002-9394(14)00295-5
DOI:
10.1016/j.ajo.2014.05.024
Reference:
AJOPHT 8930
To appear in:
American Journal of Ophthalmology
Received Date: 6 February 2014 Revised Date:
19 May 2014
Accepted Date: 21 May 2014
Please cite this article as: Alessio G, L’abbate M, Furino C, Sborgia C, La Tegola MG, Confocal Microscopy Analysis of Corneal Changes after Photorefractive Keratectomy Plus Cross-Linking for Keratoconus: 4-Year Follow-Up, American Journal of Ophthalmology (2014), doi: 10.1016/ j.ajo.2014.05.024. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT CONFOCAL MICROSCOPY ANALYSIS OF CORNEAL CHANGES AFTER PHOTOREFRACTIVE KERATECTOMY PLUS CROSS-LINKING FOR KERATOCONUS: 4-YEAR FOLLOW-UP
GIOVANNI ALESSIO, MD, MILENA L’ABBATE, MD, CLAUDIO FURINO, MD, CARLO SBORGIA, MD, MARIA GABRIELLA LA TEGOLA, MD
RI PT
CLINICA OCULISTICA DEPARTMENT OF BASIC MEDICAL SCIENCES, NEUROSCIENCE, AND SENSE ORGANS UNIVERSITY OF BARI, BARI, ITALY
SC
Short title: Confocal microscopy after excimer laser and cross-linking
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REPRINTS REQUESTS TO: MARIA GABRIELLA LA TEGOLA, MD DEPARTMENT OF BASIC MEDICAL SCIENCES, NEUROSCIENCE AND SENSE ORGANS, UNIVERSITY OF BARI, PIAZZA GIULIO CESARE, 11 - BARI – ITALY PHONE: +39/0805592058 FAX: +39/0805478918 E-MAIL ADDRESS: [email protected]
ACCEPTED MANUSCRIPT ABSTRACT
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Purpose: to analyze corneal confocal microscopy changes after the combined photorefractive keratectomy (PRK) plus cross linking (CXL) procedure. Design: prospective, interventional case series. Methods: SETTING: Department of Basic Medical Sciences, Neuroscience, and Sense Organs of the University of Bari, Bari, Italy. PATIENT/INTERVENTION: 17 eyes of 17 patients with progressive keratoconus underwent confocal microscopy examination before and after 1,3,6,12,18, 48 months following the PRK plus CXL procedure. MAIN OUTCOME MEASURES: Mean superficial epithelial cell density, mean basal epithelial cell density, mean anterior, mid, and posterior keratocyte density, qualitative analysis of stromal backscatter, sub-basal and stromal nerve density parameters, mean endothelial cell density. Results: During 4-year follow-up, the mean superficial epithelial cell density, mean basal epithelial cell density, and mean endothelial cell density remained unchanged (P>0.05); the anterior, mid stromal keratocyte density showed a significant decrease (P
S0002-9394(14)00295-5
DOI:
10.1016/j.ajo.2014.05.024
Reference:
AJOPHT 8930
To appear in:
American Journal of Ophthalmology
Received Date: 6 February 2014 Revised Date:
19 May 2014
Accepted Date: 21 May 2014
Please cite this article as: Alessio G, L’abbate M, Furino C, Sborgia C, La Tegola MG, Confocal Microscopy Analysis of Corneal Changes after Photorefractive Keratectomy Plus Cross-Linking for Keratoconus: 4-Year Follow-Up, American Journal of Ophthalmology (2014), doi: 10.1016/ j.ajo.2014.05.024. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT CONFOCAL MICROSCOPY ANALYSIS OF CORNEAL CHANGES AFTER PHOTOREFRACTIVE KERATECTOMY PLUS CROSS-LINKING FOR KERATOCONUS: 4-YEAR FOLLOW-UP
GIOVANNI ALESSIO, MD, MILENA L’ABBATE, MD, CLAUDIO FURINO, MD, CARLO SBORGIA, MD, MARIA GABRIELLA LA TEGOLA, MD
RI PT
CLINICA OCULISTICA DEPARTMENT OF BASIC MEDICAL SCIENCES, NEUROSCIENCE, AND SENSE ORGANS UNIVERSITY OF BARI, BARI, ITALY
SC
Short title: Confocal microscopy after excimer laser and cross-linking
AC C
EP
TE D
M AN U
REPRINTS REQUESTS TO: MARIA GABRIELLA LA TEGOLA, MD DEPARTMENT OF BASIC MEDICAL SCIENCES, NEUROSCIENCE AND SENSE ORGANS, UNIVERSITY OF BARI, PIAZZA GIULIO CESARE, 11 - BARI – ITALY PHONE: +39/0805592058 FAX: +39/0805478918 E-MAIL ADDRESS: [email protected]
ACCEPTED MANUSCRIPT ABSTRACT
AC C
EP
TE D
M AN U
SC
RI PT
Purpose: to analyze corneal confocal microscopy changes after the combined photorefractive keratectomy (PRK) plus cross linking (CXL) procedure. Design: prospective, interventional case series. Methods: SETTING: Department of Basic Medical Sciences, Neuroscience, and Sense Organs of the University of Bari, Bari, Italy. PATIENT/INTERVENTION: 17 eyes of 17 patients with progressive keratoconus underwent confocal microscopy examination before and after 1,3,6,12,18, 48 months following the PRK plus CXL procedure. MAIN OUTCOME MEASURES: Mean superficial epithelial cell density, mean basal epithelial cell density, mean anterior, mid, and posterior keratocyte density, qualitative analysis of stromal backscatter, sub-basal and stromal nerve density parameters, mean endothelial cell density. Results: During 4-year follow-up, the mean superficial epithelial cell density, mean basal epithelial cell density, and mean endothelial cell density remained unchanged (P>0.05); the anterior, mid stromal keratocyte density showed a significant decrease (P
