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OPEN
received: 26 April 2016 accepted: 06 July 2016 Published: 29 July 2016
Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes Yuan-Yun Tseng1,2, Yin-Chen Huang3, Tao-Chieh Yang4, Shun-Tai Yang1,2, Shou-Cheng Liu5, Tzu-Min Chang5, Yi-Chuan Kau6 & Shih-Jung Liu5,7 Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 gliomabearing rats in concurrent and virgin groups, respectively. The concentrations of all applied drugs were significantly higher in the brain than in the blood for more than 8 weeks in all studied rats. Tumor growth was more rapid in the vehicle-treated group, and tumor volumes were significantly higher in the vehicle-treated group. Moreover, the average survival time was significantly shorter in the vehicletreated group (P = 0.026), and the BIC/PLGA nanofibrous membranes significantly reduced the risk of mortality (P
OPEN
received: 26 April 2016 accepted: 06 July 2016 Published: 29 July 2016
Concurrent Chemotherapy of Malignant Glioma in Rats by Using Multidrug-Loaded Biodegradable Nanofibrous Membranes Yuan-Yun Tseng1,2, Yin-Chen Huang3, Tao-Chieh Yang4, Shun-Tai Yang1,2, Shou-Cheng Liu5, Tzu-Min Chang5, Yi-Chuan Kau6 & Shih-Jung Liu5,7 Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 gliomabearing rats in concurrent and virgin groups, respectively. The concentrations of all applied drugs were significantly higher in the brain than in the blood for more than 8 weeks in all studied rats. Tumor growth was more rapid in the vehicle-treated group, and tumor volumes were significantly higher in the vehicle-treated group. Moreover, the average survival time was significantly shorter in the vehicletreated group (P = 0.026), and the BIC/PLGA nanofibrous membranes significantly reduced the risk of mortality (P
