Chinese Journal of Cancer
Ma et al. Chin J Cancer (2017) 36:8 DOI 10.1186/s40880-016-0171-6
ORIGINAL ARTICLE
Open Access
Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae Li Ma1,2,3†, Guang‑Yu Luo1,2,4†, Yu‑Feng Ren5†, Bo Qiu1,2,3, Hong Yang1,2,6, Chun‑Xia Xie1,3, Song‑Ran Liu1,2,3, Shi‑Liang Liu1,2,3, Zhao‑Lin Chen1,2,3, Qun Li1,2,3, Jian‑Hua Fu1,2,6, Meng‑Zhong Liu1,2,3, Yong‑Hong Hu1,2,3*, Wen‑Feng Ye1,2,7* and Hui Liu1,2,3*
Abstract Background: Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squa‑ mous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret‑ rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening (NRS) before, during, and after treatment. Twenty-two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT. Results: With a median follow-up of 18 months (range, 3–39 months), patients’ 1-year overall survival (OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score (P = 0.003), increase in NRS score (P = 0.024), fistula closure (P = 0.011), and response to treatment (P
Ma et al. Chin J Cancer (2017) 36:8 DOI 10.1186/s40880-016-0171-6
ORIGINAL ARTICLE
Open Access
Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae Li Ma1,2,3†, Guang‑Yu Luo1,2,4†, Yu‑Feng Ren5†, Bo Qiu1,2,3, Hong Yang1,2,6, Chun‑Xia Xie1,3, Song‑Ran Liu1,2,3, Shi‑Liang Liu1,2,3, Zhao‑Lin Chen1,2,3, Qun Li1,2,3, Jian‑Hua Fu1,2,6, Meng‑Zhong Liu1,2,3, Yong‑Hong Hu1,2,3*, Wen‑Feng Ye1,2,7* and Hui Liu1,2,3*
Abstract Background: Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squa‑ mous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. Methods: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012. Treatment outcome and toxicity were ret‑ rospectively evaluated in 40 ESCC patients with malignant fistulae. All the 40 patients were treated with CCRT and evaluated by clinical nutritionists using nutrition risk screening (NRS) before, during, and after treatment. Twenty-two patients received a nasogastric tube, and 18 underwent percutaneous endoscopic gastrostomy feeding. The median energy intake was 2166 kcal/day. Treatment response was evaluated at 3 months after the completion of CCRT. Results: With a median follow-up of 18 months (range, 3–39 months), patients’ 1-year overall survival (OS) rate was 62.5%, and the estimated OS time was 25.5 months. Univariate analysis showed that the NRS score (P = 0.003), increase in NRS score (P = 0.024), fistula closure (P = 0.011), and response to treatment (P
