Accepted Manuscript Complications following stereotactic needle biopsy of intracranial tumors Hani Malone, MD, Jingyan Yang, MHS, Dawn L. Hershman, MD, MS, Jason D. Wright, MD, Jeffrey N. Bruce, MD, Alfred I. Neugut, MD, PhD PII:
S1878-8750(15)00588-4
DOI:
10.1016/j.wneu.2015.05.025
Reference:
WNEU 2913
To appear in:
World Neurosurgery
Received Date: 7 April 2015 Accepted Date: 18 May 2015
Please cite this article as: Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI, Complications following stereotactic needle biopsy of intracranial tumors, World Neurosurgery (2015), doi: 10.1016/j.wneu.2015.05.025. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
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Complications following stereotactic needle biopsy of intracranial tumors
SC
Hani Malone, MD1, Jingyan Yang, MHS2, Dawn L. Hershman, MD, MS2,3, Jason D. Wright, MD2,4, Jeffrey N. Bruce, MD1, and Alfred I. Neugut, MD, PhD2,3
Corresponding Author:
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EP
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Alfred I. Neugut, MD Department of Medicine Columbia University Medical Center 722 W 168th Street, Room 725 New York, NY 10032, USA Phone: 212 305-9414 Email: [email protected]
M AN U
Departments of 1Neurological Surgery, 2Epidemiology, 3Medicine, and 4Obstetrics & Gynecology, College of Physicians & Surgeons and the Mailman School of Public Health, Columbia University, New York, NY
Running title: Complications following biopsy of intracranial tumors Key words: complications, intracranial hemorrhage, brain biopsy, stereotactic needle biopsy, intracranial tumors
ACCEPTED MANUSCRIPT
Abstract: Background: Data from single institution studies suggest that perioperative complication rates following stereotactic needle brain biopsies range from 6-12%, with permanent morbidity and
RI PT
mortality ranging from 3.1-6.4% and 0-1.7%, respectively. However, no population-level data are available. We conducted a population-based analysis to study complications following needle
SC
brain biopsy.
Methods: We analyzed patients recorded in the Nationwide Inpatient Sample who underwent
M AN U
stereotactic needle brain biopsy for neoplastic lesions between 2006 and 2012. A multivariate logistic model was used to identify factors associated with complications.
Results: We identified 7514 patients who underwent biopsy for various intracranial pathologies,
TE D
including primary malignant neoplasm (52.3%), unspecified neoplasm (17.9%), metastasis (9.7%), meningioma (1.5%), radiation necrosis (0.8%), lymphoma (0.5%), and pineal region neoplasm (0.3%). Intracranial hemorrhage was the most frequent complication (5.8%). Other
EP
complications, including operative infection (0.1%) and wound breakdown (0.2%), were rare. Multivariate logistic regression analysis revealed that hemorrhage is associated with older age
AC C
(ref
S1878-8750(15)00588-4
DOI:
10.1016/j.wneu.2015.05.025
Reference:
WNEU 2913
To appear in:
World Neurosurgery
Received Date: 7 April 2015 Accepted Date: 18 May 2015
Please cite this article as: Malone H, Yang J, Hershman DL, Wright JD, Bruce JN, Neugut AI, Complications following stereotactic needle biopsy of intracranial tumors, World Neurosurgery (2015), doi: 10.1016/j.wneu.2015.05.025. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
RI PT
Complications following stereotactic needle biopsy of intracranial tumors
SC
Hani Malone, MD1, Jingyan Yang, MHS2, Dawn L. Hershman, MD, MS2,3, Jason D. Wright, MD2,4, Jeffrey N. Bruce, MD1, and Alfred I. Neugut, MD, PhD2,3
Corresponding Author:
AC C
EP
TE D
Alfred I. Neugut, MD Department of Medicine Columbia University Medical Center 722 W 168th Street, Room 725 New York, NY 10032, USA Phone: 212 305-9414 Email: [email protected]
M AN U
Departments of 1Neurological Surgery, 2Epidemiology, 3Medicine, and 4Obstetrics & Gynecology, College of Physicians & Surgeons and the Mailman School of Public Health, Columbia University, New York, NY
Running title: Complications following biopsy of intracranial tumors Key words: complications, intracranial hemorrhage, brain biopsy, stereotactic needle biopsy, intracranial tumors
ACCEPTED MANUSCRIPT
Abstract: Background: Data from single institution studies suggest that perioperative complication rates following stereotactic needle brain biopsies range from 6-12%, with permanent morbidity and
RI PT
mortality ranging from 3.1-6.4% and 0-1.7%, respectively. However, no population-level data are available. We conducted a population-based analysis to study complications following needle
SC
brain biopsy.
Methods: We analyzed patients recorded in the Nationwide Inpatient Sample who underwent
M AN U
stereotactic needle brain biopsy for neoplastic lesions between 2006 and 2012. A multivariate logistic model was used to identify factors associated with complications.
Results: We identified 7514 patients who underwent biopsy for various intracranial pathologies,
TE D
including primary malignant neoplasm (52.3%), unspecified neoplasm (17.9%), metastasis (9.7%), meningioma (1.5%), radiation necrosis (0.8%), lymphoma (0.5%), and pineal region neoplasm (0.3%). Intracranial hemorrhage was the most frequent complication (5.8%). Other
EP
complications, including operative infection (0.1%) and wound breakdown (0.2%), were rare. Multivariate logistic regression analysis revealed that hemorrhage is associated with older age
AC C
(ref
