Physiology& Behavior, Vol. 51, pp. 411--418. Pergamon Press plc, 1992. Printed in the U.S.A.

0031-9384/92 $5.00 + .00

Complex Maze Performance in Young and Aged Rats: Response to Glucose Treatment and Relationship to Blood Insulin and Glucose J. M. L O N G , * B. J. D A V I S , t P. G A R O F A L O , * E. L. S P A N G L E R * A N D D. K. I N G R A M .1

*Molecular Physiology and Genetics Section, Nathan W. Shock Laboratories, Gerontology Research Center 2 National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 ~Departments of Neurology and Neurobiology, University of Rochester School of Medicine, Rochester, NY 14627 R e c e i v e d 23 April 1991 LONG, J. M., B. J. DAVIS, P. GAROFALO, E. L. SPANGLER AND D. K. INGRAM. Complex maze performance in young and aged rats: Response to glucose treatment and relationship to blood insulin and glucose. PHYSIOL BEHAV 51(2) 411--418, 1992.--In aged rats and humans, impaired glucose regulation has been correlated with poor memory performance, and glucose treatment can result in improved performance. We tested this glucose hypothesis with rats in a 14-unit T-maze that has provided robust evidence of age-related performance decline. Aged (24-25 month) and young (6-7 month) male F-344 rats were pretrained for one-way active avoidance before receiving complex maze training (4 daily trials over 5 days) with the contingency of moving through each of 5 segments to avoid footshock. Ten min before daily training, aged rats received either saline or glucose in doses of 10, 100, or 500 mg/kg IP, while young rats received saline. Significant (ps

Complex maze performance in young and aged rats: response to glucose treatment and relationship to blood insulin and glucose.

In aged rats and humans, impaired glucose regulation has been correlated with poor memory performance, and glucose treatment can result in improved pe...
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