AIDS Research and Human Retroviruses Comparison of antibody responses to HIV infection in Ugandan Women Infected with HIV Subtypes A and D (doi: 10.1089/AID.2014.0081) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
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1 Title: Comparison of Antibody Responses to HIV Infection in Ugandan Women Infected with HIV Subtypes A and D Running title: Antibody responses in subtype A and D HIV infection Authors: Andrew F. Longosz1, Charles S. Morrison2, Pai-Lien Chen2, Hilmarie H. Brand3, Eric Arts4, Immaculate Nankya4, Robert A. Salata4, Thomas C. Quinn1, 5, Susan H. Eshleman5, Oliver Laeyendecker1,5
Associations: 1) Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, MD, USA 2) Clinical Sciences, FHI 360, Durham, NC, USA 3) The South Africain DST/NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa 4) Case Western Reserve University, Cleveland, Ohio, USA 5) Johns Hopkins University School of Medicine, Baltimore, MD, USA
Corresponding Author: Oliver Laeyendecker, MS, MBA, PhD Senior Research Associate, LIR/NIAID/NIH 855 North Wolfe St. Room 538A Baltimore, MD Phone: 410-502-3268 Fax: 410-955-9775 Email: [email protected]
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AIDS Research and Human Retroviruses Comparison of antibody responses to HIV infection in Ugandan Women Infected with HIV Subtypes A and D (doi: 10.1089/AID.2014.0081) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
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2 Key words: Keywords: HIV-1, subtype, limiting antigen assay, antibody maturation, immune response, Uganda, women
Disclaimers: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health.
Sources of Funding: This work was supported by the Centers for Disease Control and Prevention (CDC) under contract no. 200-2010-35109-00001. The research was also supported by the HIV Prevention Trials Network (HPTN) sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the Office of AIDS Research, of the National Institutes of Health (NIH), Dept. of Health and Human Services (DHHS) (UM1AI068613), and by R01 AI095068 (NIAID). Funding was also provided by The Bill and Melinda Gates Foundation (OPP1017716). Additional funding was provided by the Division of Intramural Research, NIAID, NIH.
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AIDS Research and Human Retroviruses Comparison of antibody responses to HIV infection in Ugandan Women Infected with HIV Subtypes A and D (doi: 10.1089/AID.2014.0081) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
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3 Abstract: We compared the serologic response to HIV infection in Ugandan women with HIV subtype A (n=82) and D (n=32) infection using a limiting antigen avidity assay (LAg-Avidity assay); 2,614 samples were analyzed. Study participants were followed a median of 6.6 years after HIV seroconversion. Samples were classified as assay positive if they had a LAg-Avidity assay result
Page 1 of 20
1 Title: Comparison of Antibody Responses to HIV Infection in Ugandan Women Infected with HIV Subtypes A and D Running title: Antibody responses in subtype A and D HIV infection Authors: Andrew F. Longosz1, Charles S. Morrison2, Pai-Lien Chen2, Hilmarie H. Brand3, Eric Arts4, Immaculate Nankya4, Robert A. Salata4, Thomas C. Quinn1, 5, Susan H. Eshleman5, Oliver Laeyendecker1,5
Associations: 1) Laboratory of Immunoregulation, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Baltimore, MD, USA 2) Clinical Sciences, FHI 360, Durham, NC, USA 3) The South Africain DST/NRF Centre of Excellence in Epidemiological Modelling and Analysis (SACEMA), Stellenbosch University, Stellenbosch, South Africa 4) Case Western Reserve University, Cleveland, Ohio, USA 5) Johns Hopkins University School of Medicine, Baltimore, MD, USA
Corresponding Author: Oliver Laeyendecker, MS, MBA, PhD Senior Research Associate, LIR/NIAID/NIH 855 North Wolfe St. Room 538A Baltimore, MD Phone: 410-502-3268 Fax: 410-955-9775 Email: [email protected]
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AIDS Research and Human Retroviruses Comparison of antibody responses to HIV infection in Ugandan Women Infected with HIV Subtypes A and D (doi: 10.1089/AID.2014.0081) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
Page 2 of 20
2 Key words: Keywords: HIV-1, subtype, limiting antigen assay, antibody maturation, immune response, Uganda, women
Disclaimers: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the National Institutes of Health.
Sources of Funding: This work was supported by the Centers for Disease Control and Prevention (CDC) under contract no. 200-2010-35109-00001. The research was also supported by the HIV Prevention Trials Network (HPTN) sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute on Drug Abuse (NIDA), the National Institute of Mental Health (NIMH), and the Office of AIDS Research, of the National Institutes of Health (NIH), Dept. of Health and Human Services (DHHS) (UM1AI068613), and by R01 AI095068 (NIAID). Funding was also provided by The Bill and Melinda Gates Foundation (OPP1017716). Additional funding was provided by the Division of Intramural Research, NIAID, NIH.
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AIDS Research and Human Retroviruses Comparison of antibody responses to HIV infection in Ugandan Women Infected with HIV Subtypes A and D (doi: 10.1089/AID.2014.0081) This article has been peer-reviewed and accepted for publication, but has yet to undergo copyediting and proof correction. The final published version may differ from this proof.
Page 3 of 20
3 Abstract: We compared the serologic response to HIV infection in Ugandan women with HIV subtype A (n=82) and D (n=32) infection using a limiting antigen avidity assay (LAg-Avidity assay); 2,614 samples were analyzed. Study participants were followed a median of 6.6 years after HIV seroconversion. Samples were classified as assay positive if they had a LAg-Avidity assay result
