CLINICAL RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2015; 21: 3806-3813 DOI: 10.12659/MSM.895209
Comparative Evaluation of Remifentanil and Dexmedetomidine in General Anesthesia for Cesarean Delivery
Received: 2015.07.02 Accepted: 2015.08.27 Published: 2015.12.07
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
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Chengwen Li Yandong Li Kun Wang Xiangang Kong
1 Department of Anesthesiology, Jining No. 1 People’s Hospital, Jining, Shandong, P.R. China 2 Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, P.R. China
These authors contributed equally to this work; Co-first authors Chengwen Li and Yandong Li Chengwen Li, e-mail: [email protected] Departmental sources
Use of remifentanil and dexmedetomidine in general anesthesia for cesarean section have been described. This study was designed to evaluate the effects of remifentanil and dexmedetomidine on maternal hemodynamics and bispectral index, and neonatal outcomes in elective caesarean delivery. Forty-four women undergoing elective cesarean delivery with ASA I or II and term or near-term singleton pregnancies were randomly assigned to receive remifentanil at a loading dose of 2 μg/kg over 10 min followed by a continuous infusion of 2 μg/kg/h until about 6 min before fetal delivery (Group REM), or dexmedetomidine at a loading dose of 0.4 μg/kg over 10 min followed by a continuous infusion of 0.4 μg/kg/h until about 6 min before fetal delivery (Group DEX). Maternal hemodynamics and BIS values were recorded. Neonatal effects were assessed using Apgar scores and umbilical cord blood gas analysis. Mean arterial pressure (MAP) increased after intubation in both groups, and the change magnitude of the MAP was higher in Group DEX (P
Comparative Evaluation of Remifentanil and Dexmedetomidine in General Anesthesia for Cesarean Delivery
Received: 2015.07.02 Accepted: 2015.08.27 Published: 2015.12.07
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
ABCDEF 1 ABCDEF 2 ABEF 1 ABEF 1
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Chengwen Li Yandong Li Kun Wang Xiangang Kong
1 Department of Anesthesiology, Jining No. 1 People’s Hospital, Jining, Shandong, P.R. China 2 Department of Anesthesiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, P.R. China
These authors contributed equally to this work; Co-first authors Chengwen Li and Yandong Li Chengwen Li, e-mail: [email protected] Departmental sources
Use of remifentanil and dexmedetomidine in general anesthesia for cesarean section have been described. This study was designed to evaluate the effects of remifentanil and dexmedetomidine on maternal hemodynamics and bispectral index, and neonatal outcomes in elective caesarean delivery. Forty-four women undergoing elective cesarean delivery with ASA I or II and term or near-term singleton pregnancies were randomly assigned to receive remifentanil at a loading dose of 2 μg/kg over 10 min followed by a continuous infusion of 2 μg/kg/h until about 6 min before fetal delivery (Group REM), or dexmedetomidine at a loading dose of 0.4 μg/kg over 10 min followed by a continuous infusion of 0.4 μg/kg/h until about 6 min before fetal delivery (Group DEX). Maternal hemodynamics and BIS values were recorded. Neonatal effects were assessed using Apgar scores and umbilical cord blood gas analysis. Mean arterial pressure (MAP) increased after intubation in both groups, and the change magnitude of the MAP was higher in Group DEX (P
