Janal, M. and Clark. Janal,
M.N.,
Colt,
sensitivity,
Clark,
W.C.
and Glusman,
mood and plasma endocrine
long distance running: Kemppaincn,
S.L.,
Pain
levels in man following
A., Huopaniemi,
Modification
mal sensitivity
M.,
effects of naloxone, Pain, 19 tlYH4J
P., Prrtovaara.
Karonen,
since lY75
C., lYY2. personal communication. E.W.D.,
13-25.
T.. Johansson.
third
ther-
Res.. 360 (IYXS)
33-40.
following
show that antidepressants
day of treatment,
I’., Pertovaara,
Elevation
of dental
rxercisc
A., Huopaniemi,
pain threshold
T. and Johansson.
induced in man by physical
is not reversed by cyproheptadine-mediated
of growth
hormone
Ken~ppainen, hansson,
release, Neurosci.
P.. Paalasmaa.
analgesia in man. Brain Langenfeld,
M.E..
responses
Hart,
Med. Sci. Sports Padawer. W.J. artifact?,
Exert..
E.M..
As regards
the long time elapsed since Paoli’s
Max’s discoveries.
A. and Jo-
exercise-induced
dental
at hOtY VO?
hecn faithful
intluence
of
exercise
release of stress hormones,
Ceraso,
Rollman,
G.B.
humans?.
Virtanen,
on dental
and Carswell,
O.,
Tratamiento
las
de
Biologica.
algias
Su
utilidad
Faleni,
A. and Johansson. pain
thresholds
G.,
and the
Stress
induced
PFOC. of the Psych(~nomic Society.
IYYi,
de Anestbesiologia.
R. and Mendez, terapeuticos
Psiquiatria
Biologica.
analgesia
in
Molina,
(Ed%).
Pain Therapy. Fredric
M. Levine
Paoli.
utrlisie
and perfusiJn
cndovenosa.
y toxicomanias.
Anales
dc
comme antalgiyue matem en
J.. Ag~pnianalgesia.
Proc.
1st lntern~iti(~nal
Tipt,-Lito-Palladia,.
douloureux.
In: R. IYSI.
sur faction
Rev. Neural..
Rizzi
and M.
P~~stgr~ld~t~lte Course
Venice.
F. et al.. Note preliminairc
Ies itats
Reviata
l-31.
Med.. 7 t 1963) 1073-1074.
F. and Molina.
Visentin
p. 26.
crtinicas.
2. Suppl. 1 (1973) 1X-52.
Hughes, A. et al., L’imipramine Press6
32 t lY7JJ
en depresion
de
y/o drsipramina.
de las algias
A., Desipramina
Aspectos
Armies
Y3-04.
con imipramina
en el tratamiento
carcinologie.
incoercihies,
2. Suppl. -1 (iY73)
Cerdso. 0. et al.. Agripnianalgesia analgesia: fact or
Behav., 33 f 1984) Y23-Y26.
L.M.,
route.
Psiquiatria
Argentina
Physiol.
to the intravenous
References
max’.
X3-X6.
Exercise-induced
T..
on their way
to the central nervous system. As we are concerned. we have always
131-135.
ltuopaniemi,
exposed hy Max, due
have to transit
329-332.
A.. The effect of physical exercise on dental pain threshA..
experience\ and
wonder if it would be relevant to think that the
I
use of the oral route has delayed the findings
olds. ARCS Med. Sci.. 12 (IYXa) 36. Pertovaara,
01
depression.
70 (19Khl 3Xx-3Y2.
and Kao. P.C., Plasma beta-endorphin IY (lYX7)
and Levine,
the
suppression
A.. Alila,
bicycling and running
Pain. 48 (lYY2)
Pertovaara,
attenuates
Res., 519 flYYt)l
L.S.
tu one-hour
Len.,
P.. Pertovaara,
Ci.. De~~methas(~ne
G..
are
around
this cannot br ascribed to improvement
to the meanders that oral medicaments
Kemppainen,
The
in close clinical
as analgesics, and since analgesia was present
the patient’s
G. and
of dental pain and cutaneous
by physical exercise in man, Brain
effective
102
pp.
on
1Ii- 123.
dc I’imipraminc
dam
( IUhO)503-504. Fausto J. Molina.
M.D.
Wendy J. Padawer t%~uso,lrr ,rllr. NY. 1:.s.4
PAIN PAIN
02142
07l-tl
Reply to F.J. Molina Comments
on Max et al., PAIN, 45 (1991) 3-9 We thank Dr.
Finally
the analgesic properties
ously assessed through
of desipramine
have been rigor-
the careful trial designed by M. Max and his
Paoli et al.
! Ic)bO).followed
by Hughes et al. (IYh.l),
to point out that first-generation gesic properties. in Bariloche
imipraminc,
t lY73) and Ceraso f 1Y731, among others, showed that pain was alleviated antidepressants
administered
to treat
This
procedure.
antidepressants, to the patirnt
in
implies
by Fateni
registered
intravenously.
held
and Mindez
experiences that
Later,
the administration
the technique
addition
and their
by the use of the above-mentioned
C1981) described
pain with
sants
have anal-
desipramine
were reviewed in a symposium
m 1972 where papers presented
(1973) and myself
were the first
tricyclic antidepressants
In Argentina,
actions on pain and depression
to the
et
al.
known as ‘aprypnianalgesia‘. parenteral
administration
doctor,
while
of
of a daily visit
the procedure
takes
Molina
and a variety
and the other impression
to oral drsipramine.
“around
desipramine
the third
letter
day of treatment”. desip~~mine
Molina
19x11. Ceraso
et al. tiY89f
patients
given an initial
“fails
when initiated
orally”.
of the use of intravenous such preparations
desipramine
previously
mentioned
strictness
standpoint.
X5h7 case\ nl~nti(~n~d
experiences
are
far
from
of Max and his colleagues and, from
can he considered by Ceraso
‘anecdotal’.
However.
and my own 532 patients
the an the
studied
istration
with a regimen of 50. 75. and reported
duplicate
of then
desipramine
and lasted hrtwecn
that. in contrast,
treatmcnl trials
for pain. and no
available in the LISA.
.Arc we
good?
a long-term
early responses
he a result of producing
in 50%
Yet there have been no controlled
any steady-state
dosing. The
that
immediately.
are commercially
would offer
was supr-
says that analgesia occurs
tricyclic antidepressants
missing out on something
to
clinical experience, they
on successive days t Mohna and
also reported
al.
syndromes.
he cites were hesttant
dose of SO mg of intravenous
analgesic effect was obvious Cerdso et
pain in patients
cancer pain
that intravenous
100 mg of int~v~n(~us
“the
of
authors
Molina’s
to clinical reports
relieves
claims based on uncontrolled
had the distinct rior
pain
Molina
make strong
for calling our attention
intravenous
neuropathic
1.5-Y hours”.
of antidepres-
the ‘sine qua non‘ stipulation
by the treating
Ceraso
that
For most clinical uses, we think it unlikely the
methodological orthodox
with
Although
colleagues.
place. All
suggesting
that parenterul
admin-
advantage: oral admintstration
concentration reported
higher initial
can
achieved hy mtravrnous
by Molina
and colleagues may
blood and tissue drug concen-
M.N.,
Colt,
sensitivity,
Clark,
W.C.
and Glusman,
mood and plasma endocrine
long distance running: Kemppaincn,
S.L.,
Pain
levels in man following
A., Huopaniemi,
Modification
mal sensitivity
M.,
effects of naloxone, Pain, 19 tlYH4J
P., Prrtovaara.
Karonen,
since lY75
C., lYY2. personal communication. E.W.D.,
13-25.
T.. Johansson.
third
ther-
Res.. 360 (IYXS)
33-40.
following
show that antidepressants
day of treatment,
I’., Pertovaara,
Elevation
of dental
rxercisc
A., Huopaniemi,
pain threshold
T. and Johansson.
induced in man by physical
is not reversed by cyproheptadine-mediated
of growth
hormone
Ken~ppainen, hansson,
release, Neurosci.
P.. Paalasmaa.
analgesia in man. Brain Langenfeld,
M.E..
responses
Hart,
Med. Sci. Sports Padawer. W.J. artifact?,
Exert..
E.M..
As regards
the long time elapsed since Paoli’s
Max’s discoveries.
A. and Jo-
exercise-induced
dental
at hOtY VO?
hecn faithful
intluence
of
exercise
release of stress hormones,
Ceraso,
Rollman,
G.B.
humans?.
Virtanen,
on dental
and Carswell,
O.,
Tratamiento
las
de
Biologica.
algias
Su
utilidad
Faleni,
A. and Johansson. pain
thresholds
G.,
and the
Stress
induced
PFOC. of the Psych(~nomic Society.
IYYi,
de Anestbesiologia.
R. and Mendez, terapeuticos
Psiquiatria
Biologica.
analgesia
in
Molina,
(Ed%).
Pain Therapy. Fredric
M. Levine
Paoli.
utrlisie
and perfusiJn
cndovenosa.
y toxicomanias.
Anales
dc
comme antalgiyue matem en
J.. Ag~pnianalgesia.
Proc.
1st lntern~iti(~nal
Tipt,-Lito-Palladia,.
douloureux.
In: R. IYSI.
sur faction
Rev. Neural..
Rizzi
and M.
P~~stgr~ld~t~lte Course
Venice.
F. et al.. Note preliminairc
Ies itats
Reviata
l-31.
Med.. 7 t 1963) 1073-1074.
F. and Molina.
Visentin
p. 26.
crtinicas.
2. Suppl. 1 (1973) 1X-52.
Hughes, A. et al., L’imipramine Press6
32 t lY7JJ
en depresion
de
y/o drsipramina.
de las algias
A., Desipramina
Aspectos
Armies
Y3-04.
con imipramina
en el tratamiento
carcinologie.
incoercihies,
2. Suppl. -1 (iY73)
Cerdso. 0. et al.. Agripnianalgesia analgesia: fact or
Behav., 33 f 1984) Y23-Y26.
L.M.,
route.
Psiquiatria
Argentina
Physiol.
to the intravenous
References
max’.
X3-X6.
Exercise-induced
T..
on their way
to the central nervous system. As we are concerned. we have always
131-135.
ltuopaniemi,
exposed hy Max, due
have to transit
329-332.
A.. The effect of physical exercise on dental pain threshA..
experience\ and
wonder if it would be relevant to think that the
I
use of the oral route has delayed the findings
olds. ARCS Med. Sci.. 12 (IYXa) 36. Pertovaara,
01
depression.
70 (19Khl 3Xx-3Y2.
and Kao. P.C., Plasma beta-endorphin IY (lYX7)
and Levine,
the
suppression
A.. Alila,
bicycling and running
Pain. 48 (lYY2)
Pertovaara,
attenuates
Res., 519 flYYt)l
L.S.
tu one-hour
Len.,
P.. Pertovaara,
Ci.. De~~methas(~ne
G..
are
around
this cannot br ascribed to improvement
to the meanders that oral medicaments
Kemppainen,
The
in close clinical
as analgesics, and since analgesia was present
the patient’s
G. and
of dental pain and cutaneous
by physical exercise in man, Brain
effective
102
pp.
on
1Ii- 123.
dc I’imipraminc
dam
( IUhO)503-504. Fausto J. Molina.
M.D.
Wendy J. Padawer t%~uso,lrr ,rllr. NY. 1:.s.4
PAIN PAIN
02142
07l-tl
Reply to F.J. Molina Comments
on Max et al., PAIN, 45 (1991) 3-9 We thank Dr.
Finally
the analgesic properties
ously assessed through
of desipramine
have been rigor-
the careful trial designed by M. Max and his
Paoli et al.
! Ic)bO).followed
by Hughes et al. (IYh.l),
to point out that first-generation gesic properties. in Bariloche
imipraminc,
t lY73) and Ceraso f 1Y731, among others, showed that pain was alleviated antidepressants
administered
to treat
This
procedure.
antidepressants, to the patirnt
in
implies
by Fateni
registered
intravenously.
held
and Mindez
experiences that
Later,
the administration
the technique
addition
and their
by the use of the above-mentioned
C1981) described
pain with
sants
have anal-
desipramine
were reviewed in a symposium
m 1972 where papers presented
(1973) and myself
were the first
tricyclic antidepressants
In Argentina,
actions on pain and depression
to the
et
al.
known as ‘aprypnianalgesia‘. parenteral
administration
doctor,
while
of
of a daily visit
the procedure
takes
Molina
and a variety
and the other impression
to oral drsipramine.
“around
desipramine
the third
letter
day of treatment”. desip~~mine
Molina
19x11. Ceraso
et al. tiY89f
patients
given an initial
“fails
when initiated
orally”.
of the use of intravenous such preparations
desipramine
previously
mentioned
strictness
standpoint.
X5h7 case\ nl~nti(~n~d
experiences
are
far
from
of Max and his colleagues and, from
can he considered by Ceraso
‘anecdotal’.
However.
and my own 532 patients
the an the
studied
istration
with a regimen of 50. 75. and reported
duplicate
of then
desipramine
and lasted hrtwecn
that. in contrast,
treatmcnl trials
for pain. and no
available in the LISA.
.Arc we
good?
a long-term
early responses
he a result of producing
in 50%
Yet there have been no controlled
any steady-state
dosing. The
that
immediately.
are commercially
would offer
was supr-
says that analgesia occurs
tricyclic antidepressants
missing out on something
to
clinical experience, they
on successive days t Mohna and
also reported
al.
syndromes.
he cites were hesttant
dose of SO mg of intravenous
analgesic effect was obvious Cerdso et
pain in patients
cancer pain
that intravenous
100 mg of int~v~n(~us
“the
of
authors
Molina’s
to clinical reports
relieves
claims based on uncontrolled
had the distinct rior
pain
Molina
make strong
for calling our attention
intravenous
neuropathic
1.5-Y hours”.
of antidepres-
the ‘sine qua non‘ stipulation
by the treating
Ceraso
that
For most clinical uses, we think it unlikely the
methodological orthodox
with
Although
colleagues.
place. All
suggesting
that parenterul
admin-
advantage: oral admintstration
concentration reported
higher initial
can
achieved hy mtravrnous
by Molina
and colleagues may
blood and tissue drug concen-
