Iranian Journal of Pharmaceutical Research (2016), 15 (2): 583-589 Received: July 2014 Accepted: December 2014

Copyright © 2016 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services

Original Article

Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats Esrafil Mansouri a, Ameneh Hardanib, Mohamad Reza Afzalzadehc, Ashraf Amir zargard and Zakiaeh Meamare* Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Iran. bDepartment of Public Health, Faculty of Hygiene Sciences, Ahvaz Jundishapur University of Medical Sciences, Iran. cDepartment of Physiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran. dDepartment of Physiology and Diabetes Research Center, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Iran. eDepartment of Engineering Environmental Health, Faculty of Hygiene Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. a

Abstract Retinoic acid and Rosa damascena are compounds that have considerable effects in the cellular proliferation and synthesis of extracellular matrix. The present study was designed to assess the combined effects of retinoic acid and Rosa damascena mill on wound in diabetic rats. Seventy-two rats were used in this study. Diabetes was induced by a single intraperitoneal injection of streptozotocin (60 mg. Kg-1). Then, a full thickness wound was created on dorsal surface of all animals. After that, rats were divided, into three groups; control (normal saline), positive control (Phenytoin), and  case (combined of 0.1% Tretinoein lotion and hydroalcoholic extract of Rosa damascena mill). Afterward, wounds were evaluated macroscopically and microscopically on days 5, 10 and 15. Macroscopic and microscopic evaluations showed a significant improvement (p E0.06). These results have been shown in Figure 2. et al. / IJPR (2016), 15 (2): 583-589

Figure 2. The comparison of mean ± SD in percentage of wound healing in evaluated groups on 5th, 10th and 15th days in different groups. A (normal saline solution), B (Phenytoin) and C (a combined of 0.1% Tretinoin lotion and hydro-alcoholic extract of Rosa damascena mill ). ‫٭‬compared to A group ( P < 0.05). ‫٭٭‬compared with C group (P < 0.05).

Figure 2. The comparison of mean ± SD in percentage of wound healing in evaluated groups on 5thwhile , 10th an andacute 15th and daysmild in different groups. B (Phenytoin) and C (a inflammation mayAbe(normal saline solution),Result seen in the wound.

combined of 0.1% Tretinoin lotion andstart hydro-alcoholic extract of Rosa damascena mill ). Point 2, is associated with the of Macroscopic evaluation

epithelial cells renewal around and base of the Macroscopic evaluation on the 5th day ‫٭‬compared A group (P< 0.05).of‫٭٭‬compared C group that (P

Combined Effects of Retinoic Acid and Hydro-Alcoholic Extract of Rosa Damascena Mill on Wound in Diabetic Rats.

Retinoic acid and Rosa damascena are compounds that have considerable effects in the cellular proliferation and synthesis of extracellular matrix. The...
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