RESEARCH ARTICLE
Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction Xiyou Wang1, Chuanhai Liu2, Yong Xu3, Ping Chen1, Yue Shen1, Yansheng Xu1, Yubo Zhao1, Weihao Chen1, Xinyu Zhang1, Yun Ouyang1, Yi Wang1, Changliang Xie1, Maojun Zhou1, Cuilong Liu1* 1 Department of Urology, PLA Navy General Hospital, Hai dian District, Beijing, People’s Republic of China, 2 Department of Urology, The Second Artillery General Hospital of Chinese People’s Liberation Army, Xicheng District, Beijing, People’s Republic of China, 3 Department of Urology, PLA General Hospital, Hai dian District, Beijing, People’s Republic of China
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OPEN ACCESS Citation: Wang X, Liu C, Xu Y, Chen P, Shen Y, Xu Y, et al. (2017) Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction. PLoS ONE 12(3): e0174145. https://doi.org/10.1371/ journal.pone.0174145 Editor: Dengshun Miao, Nanjing Medical University, CHINA Received: November 6, 2016 Accepted: February 16, 2017 Published: March 28, 2017 Copyright: © 2017 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
* [email protected]
Abstract The present study was aimed to examine whether icariin, a traditional Chinese medicine, could improve therapeutic effects of adipose derived mesenchymal stem cells (ADSCs) for diabetes-associated erectile dysfunction (DMED). DMED were induced in rats by intraperitoneal injection of streptozotocin and confirmed by erectile function measurement. Then, rats of diabetic ED were randomly divided to receive the treatment of saline, ADSCs, icariin or ADSCs combined with icariin respectively. Compared with the treatment by ADSCs or icariin alone, intracavernosum injection of ADSCs combined with the following daily gastric gavage of icariin significantly augmented the value of ICP and ICP/MAP (p
Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction Xiyou Wang1, Chuanhai Liu2, Yong Xu3, Ping Chen1, Yue Shen1, Yansheng Xu1, Yubo Zhao1, Weihao Chen1, Xinyu Zhang1, Yun Ouyang1, Yi Wang1, Changliang Xie1, Maojun Zhou1, Cuilong Liu1* 1 Department of Urology, PLA Navy General Hospital, Hai dian District, Beijing, People’s Republic of China, 2 Department of Urology, The Second Artillery General Hospital of Chinese People’s Liberation Army, Xicheng District, Beijing, People’s Republic of China, 3 Department of Urology, PLA General Hospital, Hai dian District, Beijing, People’s Republic of China
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OPEN ACCESS Citation: Wang X, Liu C, Xu Y, Chen P, Shen Y, Xu Y, et al. (2017) Combination of mesenchymal stem cell injection with icariin for the treatment of diabetes-associated erectile dysfunction. PLoS ONE 12(3): e0174145. https://doi.org/10.1371/ journal.pone.0174145 Editor: Dengshun Miao, Nanjing Medical University, CHINA Received: November 6, 2016 Accepted: February 16, 2017 Published: March 28, 2017 Copyright: © 2017 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist.
* [email protected]
Abstract The present study was aimed to examine whether icariin, a traditional Chinese medicine, could improve therapeutic effects of adipose derived mesenchymal stem cells (ADSCs) for diabetes-associated erectile dysfunction (DMED). DMED were induced in rats by intraperitoneal injection of streptozotocin and confirmed by erectile function measurement. Then, rats of diabetic ED were randomly divided to receive the treatment of saline, ADSCs, icariin or ADSCs combined with icariin respectively. Compared with the treatment by ADSCs or icariin alone, intracavernosum injection of ADSCs combined with the following daily gastric gavage of icariin significantly augmented the value of ICP and ICP/MAP (p
