archives of oral biology 59 (2014) 1233–1241
Available online at www.sciencedirect.com
ScienceDirect journal homepage: http://www.elsevier.com/locate/aob
Combination effects of baicalein with antibiotics against oral pathogens Eun-Jin Jang a, Su-Mi Cha b, Sung-Mi Choi c, Jeong-Dan Cha d,* a
Department of Dental Technology, Daegu Health College, Daegu, South Korea Department of Oral Microbiology and Institute of Oral Bioscience, Chonbuk National University, Jeonju, South Korea c Department of Dental Hygiene, Daegu Health College, Daegu, South Korea d Department of Natural Product Research, Institute of Jinan red ginseng, Jinan, South Korea b
article info
abstract
Article history:
Background: Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi, which
Accepted 13 July 2014
has long been used in Asia as herbal medicine. Several biological effects of baicalein, such as antiviral, anti-inflammatiom, anti-hepatotoxicity, and anti-tumour properties, have been
Keywords:
reported.
Baicalein
Objective and design: In this study, the antibacterial activities of baicalein were investigated
Minimum inhibitory concentrations
in combination with ampicillin and/or gentamicin against oral bacteria.
(MICs)
Results: Baicalein was determined with MIC and MBC values ranging from 80 to 320 and 160
Minimum bactericidal
to 640 mg/mL against oral bacteria. The range of MIC50 and MIC90 were 20–160 mg/mL and 80–
concentrations (MBCs)
320 mg/mL, respectively. The combination effects of baicalein with antibiotics were syner-
Fractional inhibitory concentration
gistic (FIC index
Available online at www.sciencedirect.com
ScienceDirect journal homepage: http://www.elsevier.com/locate/aob
Combination effects of baicalein with antibiotics against oral pathogens Eun-Jin Jang a, Su-Mi Cha b, Sung-Mi Choi c, Jeong-Dan Cha d,* a
Department of Dental Technology, Daegu Health College, Daegu, South Korea Department of Oral Microbiology and Institute of Oral Bioscience, Chonbuk National University, Jeonju, South Korea c Department of Dental Hygiene, Daegu Health College, Daegu, South Korea d Department of Natural Product Research, Institute of Jinan red ginseng, Jinan, South Korea b
article info
abstract
Article history:
Background: Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi, which
Accepted 13 July 2014
has long been used in Asia as herbal medicine. Several biological effects of baicalein, such as antiviral, anti-inflammatiom, anti-hepatotoxicity, and anti-tumour properties, have been
Keywords:
reported.
Baicalein
Objective and design: In this study, the antibacterial activities of baicalein were investigated
Minimum inhibitory concentrations
in combination with ampicillin and/or gentamicin against oral bacteria.
(MICs)
Results: Baicalein was determined with MIC and MBC values ranging from 80 to 320 and 160
Minimum bactericidal
to 640 mg/mL against oral bacteria. The range of MIC50 and MIC90 were 20–160 mg/mL and 80–
concentrations (MBCs)
320 mg/mL, respectively. The combination effects of baicalein with antibiotics were syner-
Fractional inhibitory concentration
gistic (FIC index
