Articles in PresS. Am J Physiol Regul Integr Comp Physiol (March 18, 2015). doi:10.1152/ajpregu.00010.2015 1
Cognitive and perceptual responses during passive heat stress in younger and
2
older adults
3 4
Zachary J. Schlader1,2, Daniel Gagnon1, Amy Adams1, Eric Rivas1,3, C. Munro Cullum4, Craig G. Crandall1
5 6
1
7
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
8
2
Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY
9
3
Department of Kinesiology, Texas Woman’s University, Denton, TX
10
4
Departments of Psychiatry and Neurology & Neurotherapeutics, University of Texas Southwestern Medical
11
Center, Dallas, TX
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Department of
12 13 14
Corresponding Author:
15
Craig G. Crandall, PhD
16
Institute for Exercise and Environmental Medicine
17
7232 Greenville Ave
18
Dallas, TX, 75231, USA
19
Email: [email protected]
20
Phone: 214-345-4623
21 22
Running Head: Age and cognition during passive heat stress
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Word Count: 4424
24
Abstract Word Count: 243
25
Number of References: 68
26
Number of Tables: 3
27
Number of Figures: 4
28
Keywords: Cognitive function, aging, hyperthermia, thermal comfort
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1 Copyright © 2015 by the American Physiological Society.
30
Abstract
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We tested the hypothesis that attention, memory, and executive function are impaired to a greater extent in
32
passively heat stressed older, compared to younger, adults. In a randomized, crossover design, 15 older (age:
33
69 ± 5 y) and 14 younger (age: 30 ± 4 y) healthy subjects underwent passive heat stress and time control
34
trials. Cognitive tests (outcomes: accuracy and reaction time) from the CANTAB battery evaluated attention
35
[rapid visual processing (RVP), choice reaction time (CRT)], memory [spatial span (SSP), pattern recognition
36
memory (PRM)], and executive function [one touch stockings of Cambridge (OTS)]. Testing was undertaken on
37
two occasions during each trial, at baseline and after internal temperature had increased by 1.0 ± 0.2°C or
38
after a time control period. Attention: Reaction time during RVP and CRT was slower (P≤0.01) in the older
39
group. During heat stress, RVP reaction time improved (P
Cognitive and perceptual responses during passive heat stress in younger and
2
older adults
3 4
Zachary J. Schlader1,2, Daniel Gagnon1, Amy Adams1, Eric Rivas1,3, C. Munro Cullum4, Craig G. Crandall1
5 6
1
7
Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
8
2
Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY
9
3
Department of Kinesiology, Texas Woman’s University, Denton, TX
10
4
Departments of Psychiatry and Neurology & Neurotherapeutics, University of Texas Southwestern Medical
11
Center, Dallas, TX
Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Department of
12 13 14
Corresponding Author:
15
Craig G. Crandall, PhD
16
Institute for Exercise and Environmental Medicine
17
7232 Greenville Ave
18
Dallas, TX, 75231, USA
19
Email: [email protected]
20
Phone: 214-345-4623
21 22
Running Head: Age and cognition during passive heat stress
23
Word Count: 4424
24
Abstract Word Count: 243
25
Number of References: 68
26
Number of Tables: 3
27
Number of Figures: 4
28
Keywords: Cognitive function, aging, hyperthermia, thermal comfort
29
1 Copyright © 2015 by the American Physiological Society.
30
Abstract
31
We tested the hypothesis that attention, memory, and executive function are impaired to a greater extent in
32
passively heat stressed older, compared to younger, adults. In a randomized, crossover design, 15 older (age:
33
69 ± 5 y) and 14 younger (age: 30 ± 4 y) healthy subjects underwent passive heat stress and time control
34
trials. Cognitive tests (outcomes: accuracy and reaction time) from the CANTAB battery evaluated attention
35
[rapid visual processing (RVP), choice reaction time (CRT)], memory [spatial span (SSP), pattern recognition
36
memory (PRM)], and executive function [one touch stockings of Cambridge (OTS)]. Testing was undertaken on
37
two occasions during each trial, at baseline and after internal temperature had increased by 1.0 ± 0.2°C or
38
after a time control period. Attention: Reaction time during RVP and CRT was slower (P≤0.01) in the older
39
group. During heat stress, RVP reaction time improved (P
