MOLECULAR MEDICINE REPORTS 13: 1551-1557, 2016
Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer YUTAKA KIMURA1, SATOKO MOROHASHI2, TADASHI YOSHIZAWA1,2, TAKAHIRO SUZUKI2, HAJIME MOROHASHI1, YOSHIYUKI SAKAMOTO1, MOTOI KOYAMA1, AKIHIKO MURATA1, HIROSHI KIJIMA2 and KENICHI HAKAMADA1 Departments of 1Gastroenterological Surgery, and 2Pathology and Bioscience, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori 036‑8562, Japan Received October 28, 2014; Accepted July 28, 2015 DOI: 10.3892/mmr.2015.4687 Abstract. Colorectal cancer is a common malignant disease, the incidence of which is increasing worldwide, therefore, identifying novel prognostic factors to improve adjuvant therapeutic strategies or postoperative monitoring is required. Angiogenesis, which is assessed by microvessel density (MVD), is significant in tumor growth and metastasis. However, the association between angiogenesis and clinical outcome remains controversial. In the present study, 84 surgically resected cases of colorectal cancer were examined to clarify the clinicopathological significance of vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and cluster of differentiation (CD)34 expression levels. VEGF expression was identified to be significantly correlated with TP expression (r=0.45; P
Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer YUTAKA KIMURA1, SATOKO MOROHASHI2, TADASHI YOSHIZAWA1,2, TAKAHIRO SUZUKI2, HAJIME MOROHASHI1, YOSHIYUKI SAKAMOTO1, MOTOI KOYAMA1, AKIHIKO MURATA1, HIROSHI KIJIMA2 and KENICHI HAKAMADA1 Departments of 1Gastroenterological Surgery, and 2Pathology and Bioscience, Hirosaki University Graduate School of Medicine and Hospital, Hirosaki, Aomori 036‑8562, Japan Received October 28, 2014; Accepted July 28, 2015 DOI: 10.3892/mmr.2015.4687 Abstract. Colorectal cancer is a common malignant disease, the incidence of which is increasing worldwide, therefore, identifying novel prognostic factors to improve adjuvant therapeutic strategies or postoperative monitoring is required. Angiogenesis, which is assessed by microvessel density (MVD), is significant in tumor growth and metastasis. However, the association between angiogenesis and clinical outcome remains controversial. In the present study, 84 surgically resected cases of colorectal cancer were examined to clarify the clinicopathological significance of vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and cluster of differentiation (CD)34 expression levels. VEGF expression was identified to be significantly correlated with TP expression (r=0.45; P
