Int J Clin Exp Pathol 2014;7(7):4545-4551 www.ijcep.com /ISSN:1936-2625/IJCEP0000819

Original Article Clinicopathological and prognostic significance of microRNA-107 in human non small cell lung cancer Kai-Ze Zhong1*, Wei-Wen Chen2*, Xiao-Yan Hu2, An-Li Jiang2, Jian Zhao1 Department of Thoracic surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China; 2Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan, Shandong 250012, China. *Equal contributors. 1

Received May 18, 2014; Accepted June 26, 2014; Epub June 15, 2014; Published July 1, 2014 Abstract: Background: MicroRNAs (miRNAs) are small, non-coding RNAs which can function as oncogenes or tumor suppressor genes in human cancers. Researchers have found that the expression level of miR-107 was decreased in human non-small cell lung cancer (NSCLC) tissues and cell lines, however, its clinicopathological and prognostic significance in NSCLC has not been investigated. Methods: Quantitative real-time PCR (qRT-PCR) was used to analyze the expression of miR-107 in 137 pairs of fresh NSCLC and matched adjacent normal tissue specimens. The chi-square test and Fishers exact tests were used to examine the associations between miR-107 expression and the clinicopathological characters. The overall survival (OS) and progression-free survival (PFS) were analyzed by log-rank test, and survival curves were plotted according to Kaplan-Meier. Results: The expression level of miR107 was significantly lower in tumor tissues than that in corresponding noncancerous tissues (0.4676±0.2078 vs. 1.000±0.3953, P