Br. J. clin. Pharmac. (1979), 7, 129S
CLINICAL STUDY OF CLOBAZAM IN PATIENTS WITH GASTROINTESTINAL DISORDERS 0. LAUDANO Department of Medicine, Rosario University School of Medicine, Hospital Centenario, Rosario, Argentina
THE efficacy of clobazam and diazepam in the treatment of anxious patients with gastrointestinal disorders has been compared in a double blind study (Laudano et al., 1977). Thirty-four patients with symptoms of peptic ulcer were classified as "organic" (with radiologically proven disease) or "functional" (X-ray negative). A standard clinical regimen was instituted for all patients with dietary measures, antacids and anticholinergic drugs. In addition patients were randomly allocated to treatment with either diazepam 5 mg three times daily or clobazam 10 mg three times daily for 6 weeks. Patients were assessed at the beginning and end of treatment by means of the Psychoticism, extroversion and neuroticism (PEN) inventory (Eysenck & Eysenck, 1969) and the Taylor Manifest Anxiety Scale (TMAS), and in addition the Hamilton Anxiety Scale (HAS) and Wittenborn Psychiatric Rating Scales were completed at
weekly intervals. The two treatment groups were similar in terms of age, sex, diagnosis and basal trait and state anxiety. Both groups showed a significant reduction in HAS scores during treatment (P
CLINICAL STUDY OF CLOBAZAM IN PATIENTS WITH GASTROINTESTINAL DISORDERS 0. LAUDANO Department of Medicine, Rosario University School of Medicine, Hospital Centenario, Rosario, Argentina
THE efficacy of clobazam and diazepam in the treatment of anxious patients with gastrointestinal disorders has been compared in a double blind study (Laudano et al., 1977). Thirty-four patients with symptoms of peptic ulcer were classified as "organic" (with radiologically proven disease) or "functional" (X-ray negative). A standard clinical regimen was instituted for all patients with dietary measures, antacids and anticholinergic drugs. In addition patients were randomly allocated to treatment with either diazepam 5 mg three times daily or clobazam 10 mg three times daily for 6 weeks. Patients were assessed at the beginning and end of treatment by means of the Psychoticism, extroversion and neuroticism (PEN) inventory (Eysenck & Eysenck, 1969) and the Taylor Manifest Anxiety Scale (TMAS), and in addition the Hamilton Anxiety Scale (HAS) and Wittenborn Psychiatric Rating Scales were completed at
weekly intervals. The two treatment groups were similar in terms of age, sex, diagnosis and basal trait and state anxiety. Both groups showed a significant reduction in HAS scores during treatment (P
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