Accepted Manuscript Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer Hua Zhang, MD, Honggang Xia, MD, Lianmin Zhang, MD, Bin Zhang, Ph.D, Dongsheng Yue, Ph.D, Changli wang, Ph.D PII:
S0002-9610(15)00290-1
DOI:
10.1016/j.amjsurg.2015.03.022
Reference:
AJS 11539
To appear in:
The American Journal of Surgery
Received Date: 18 October 2014 Revised Date:
24 January 2015
Accepted Date: 30 March 2015
Please cite this article as: Zhang H, Xia H, Zhang L, Zhang B, Yue D, wang C, Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer, The American Journal of Surgery (2015), doi: 10.1016/ j.amjsurg.2015.03.022. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
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Title Page Complete manuscript title: Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer Hua Zhang1, MD; Honggang Xia2, MD; Lianmin Zhang1, MD; Bin Zhang1, Ph.D; Dongsheng Yue1, Ph.D; Changli wang1, Ph.D 1 Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Huanhuxi Road, Hexi District, Tianjin, China. 2 Department of Thoracic Surgery, Tianjin Haibin people’s Hospital, Nanhuan Road, Binhaixin District, Tianjin, China. The corresponding author: Changli Wang, Email: [email protected], telephone number: +008613652022551, fax number: 0086-22-23340123. Address: Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, China.
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Abstract Background: Our aim was to determinate the prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in primary operable patients with non-small cell lung cancer (NSCLC). Methods: 678 NSCLC patients were enrolled in this study. The prognostic significance of both markers was determined by both univariate and multivariate Cox survival analysis. The cut-off value for NLR and PLR was selected by using receiver operating characteristic (ROC) curve analysis. Results: Multivariate analysis showed that NLR was an independent prognostic factor for DFS (hazard ratio [HR]=1.593, 95% confidence interval [CI] 1.277 to 1.988, P
S0002-9610(15)00290-1
DOI:
10.1016/j.amjsurg.2015.03.022
Reference:
AJS 11539
To appear in:
The American Journal of Surgery
Received Date: 18 October 2014 Revised Date:
24 January 2015
Accepted Date: 30 March 2015
Please cite this article as: Zhang H, Xia H, Zhang L, Zhang B, Yue D, wang C, Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer, The American Journal of Surgery (2015), doi: 10.1016/ j.amjsurg.2015.03.022. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
AC C
EP
TE D
M AN U
SC
RI PT
Title Page Complete manuscript title: Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in primary operable patients with non-small cell lung cancer Hua Zhang1, MD; Honggang Xia2, MD; Lianmin Zhang1, MD; Bin Zhang1, Ph.D; Dongsheng Yue1, Ph.D; Changli wang1, Ph.D 1 Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Lung Cancer Center, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Huanhuxi Road, Hexi District, Tianjin, China. 2 Department of Thoracic Surgery, Tianjin Haibin people’s Hospital, Nanhuan Road, Binhaixin District, Tianjin, China. The corresponding author: Changli Wang, Email: [email protected], telephone number: +008613652022551, fax number: 0086-22-23340123. Address: Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Hexi District, Tianjin 300060, China.
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ACCEPTED MANUSCRIPT
SC
RI PT
Abstract Background: Our aim was to determinate the prognostic value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in primary operable patients with non-small cell lung cancer (NSCLC). Methods: 678 NSCLC patients were enrolled in this study. The prognostic significance of both markers was determined by both univariate and multivariate Cox survival analysis. The cut-off value for NLR and PLR was selected by using receiver operating characteristic (ROC) curve analysis. Results: Multivariate analysis showed that NLR was an independent prognostic factor for DFS (hazard ratio [HR]=1.593, 95% confidence interval [CI] 1.277 to 1.988, P
