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MOLECULAR AND CLINICAL ONCOLOGY 4: 994-1002, 2016
Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer YASUHIRO INOUE, SUSUMU SAIGUSA, JUNICHIRO HIRO, YUJI TOIYAMA, TOSHIMITSU ARAKI, KOJI TANAKA, YAUSHIKO MOHRI and MASATO KUSUNOKI Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan Received August 25, 2015; Accepted March 16, 2016 DOI: 10.3892/mco.2016.855 Abstract. Preoperative chemoradiotherapy (CRT) with total mesorectal excision (TME) is the widely accepted treatment for rectal cancer (RC) in Western countries. However, there remains controversy as to whether preoperative CRT is useful in tumors that extend beyond the mesorectum, including metastasis to the lateral pelvic lymph nodes (LPLN). The aim of this study was to assess the prognostic significance of LPLN enlargement in patients with RC who receive preoperative CRT followed by TME without LPLN dissection. We evaluated the prognostic effect of radiographic LPLN enlargement before and after CRT, as well as the patients' clinicopathological and genetic profiles. Of the 104 patients investigated, pretreatment imaging identified 19 (18%) as LPLN‑positive (>7 mm in diameter). Of these 19 patients, 7 (37%) exhibited LPLN downsizing to 7 mm in the long‑axis diameter in the lateral pelvic area, according to previous reports (9,10). Reduction of LPLN size following preoperative CRT was defined as initially positive LPLN downsized to
MOLECULAR AND CLINICAL ONCOLOGY 4: 994-1002, 2016
Clinical significance of enlarged lateral pelvic lymph nodes before and after preoperative chemoradiotherapy for rectal cancer YASUHIRO INOUE, SUSUMU SAIGUSA, JUNICHIRO HIRO, YUJI TOIYAMA, TOSHIMITSU ARAKI, KOJI TANAKA, YAUSHIKO MOHRI and MASATO KUSUNOKI Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan Received August 25, 2015; Accepted March 16, 2016 DOI: 10.3892/mco.2016.855 Abstract. Preoperative chemoradiotherapy (CRT) with total mesorectal excision (TME) is the widely accepted treatment for rectal cancer (RC) in Western countries. However, there remains controversy as to whether preoperative CRT is useful in tumors that extend beyond the mesorectum, including metastasis to the lateral pelvic lymph nodes (LPLN). The aim of this study was to assess the prognostic significance of LPLN enlargement in patients with RC who receive preoperative CRT followed by TME without LPLN dissection. We evaluated the prognostic effect of radiographic LPLN enlargement before and after CRT, as well as the patients' clinicopathological and genetic profiles. Of the 104 patients investigated, pretreatment imaging identified 19 (18%) as LPLN‑positive (>7 mm in diameter). Of these 19 patients, 7 (37%) exhibited LPLN downsizing to 7 mm in the long‑axis diameter in the lateral pelvic area, according to previous reports (9,10). Reduction of LPLN size following preoperative CRT was defined as initially positive LPLN downsized to
