Original Article - Urological Oncology Korean J Urol 2015;56:565-571. http://dx.doi.org/10.4111/kju.2015.56.8.565 pISSN 2005-6737 • eISSN 2005-6745
Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia Donghyun Lee, Chunwoo Lee, Taekmin Kwon1, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 1Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
Purpose: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). Materials and Methods: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups—patients with and without HGPIN—and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. Results: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p
Clinical features and prognosis of prostate cancer with high-grade prostatic intraepithelial neoplasia Donghyun Lee, Chunwoo Lee, Taekmin Kwon1, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 1Department of Urology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea
Purpose: To evaluate the clinical features and biochemical recurrence (BCR) in prostate cancer (PCa) with high-grade prostatic intraepithelial neoplasia (HGPIN). Materials and Methods: We retrospectively analyzed the medical records of 893 patients who underwent a radical prostatectomy for PCa between 2011 and 2012 at Asan Medical Center; 752 of these patients who did not receive neoadjuvant or adjuvant therapy and were followed up for more than 1 year were included. The cohort was divided into two groups—patients with and without HGPIN—and their characteristics were compared. The Cox proportional hazards model was used to analyze factors affecting BCR. Results: In total, 652 study patients (86.7%) had HGPIN. There were no significant differences in preoperative factors between the two groups, including age (p=0.369) and preoperative prostate-specific antigen concentration (p=0.234). Patients with HGPIN had a higher Gleason score (p=0.012), more frequent multiple tumor (p=0.013), and more perineural invasion (p=0.012), but no other postoperative pathologic characteristics were significantly different between the two groups. There were no significant differences in BCR (13.0% vs. 11.5%, p=0.665) and HGPIN was not associated with BCR (p=0.745). In multivariate analysis, only the T stage (p
