Accepted Manuscript Title: Clinical Correlates of Parametric Digit-Symbol Substitution Test in Schizophrenia Author: Anekal C. Amaresha Vijay Danivas Venkataram Shivakumar Sri Mahavir Agarwal Sunil V. Kalmady Janardhanan C. Narayanaswamy Ganesan Venkatasubramanian PII: DOI: Reference:
S1876-2018(14)00085-9 http://dx.doi.org/doi:10.1016/j.ajp.2014.03.010 AJP 578
To appear in: Received date: Accepted date:
12-11-2013 7-3-2014
Please cite this article as: Amareshaa,b,A.C.,Danivasa,b,V., a,b,V., a,b,S.M., a,b,S.V., Shivakumar Agarwal Kalmady Narayanaswamya,b,J.C., Venkatasubramaniana,b,G., Clinical Correlates of Parametric DigitSymbol Substitution Test in Schizophrenia, Asian Journal of Psychiatry (2014), http://dx.doi.org/10.1016/j.ajp.2014.03.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Original Research Title: Clinical Correlates of Parametric Digit-Symbol Substitution Test in Schizophrenia
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Anekal C. Amaresha1,2, Vijay Danivas1,2, Venkataram Shivakumar1,2, Sri Mahavir Agarwal1,2, Sunil V. Kalmady1,2, Janardhanan C. Narayanaswamy1,2, Ganesan Venkatasubramanian1,2*
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¹Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India 2 Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bangalore, India
*Corresponding author:
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Word count Abstract: 200 Manuscript Text: 2713 Tables: 2 Figures: 3
M
an
Dr. G. Venkatasubramanian MD, PhD Additional Professor of Psychiatry & Wellcome Trust / DBT India Alliance Senior Fellow Department of Psychiatry National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore E-mail: [email protected] Phone: 080-26995256 Fax: 0091-80-26564830 / 26562121
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Acknowledgement: This research work is supported by the Wellcome Trust / DBT India Alliance Senior Fellowship Research Grant to GV. ACA, SVK & SMA are supported by Wellcome Trust / DBT India Alliance. VS is supported by the Indian Council of Medical Research. JCN is supported by the Department of Science & Technology, Government of India.
1 Page 1 of 20
Abstract Processing speed deficit, ascertained by Digit-Symbol Substitution Test (DSST), is considered as a
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fundamental impairment in Schizophrenia. Clinical correlates of processing speed abnormalities, especially using the parametric version of DSST is yet to be evaluated comprehensively. In this
cr
study, we examined schizophrenia patients (N=66) and demographically-matched healthy controls
us
(N=72) using computer-administered parametric DSST (pDSST) with fixed (pDSSTF) as well as random (pDSSTR) conditions & analysed the relationship between pDSST performance and clinical
an
symptoms. Psychopathology was assessed using Scale for Assessment of Positive Symptoms (SAPS) / Negative Symptoms (SANS) with good inter-rater reliability. In comparison with healthy controls,
M
patients demonstrated significantly lesser number of correct responses (CN) in pDSSTF (t=8.0; p
S1876-2018(14)00085-9 http://dx.doi.org/doi:10.1016/j.ajp.2014.03.010 AJP 578
To appear in: Received date: Accepted date:
12-11-2013 7-3-2014
Please cite this article as: Amareshaa,b,A.C.,Danivasa,b,V., a,b,V., a,b,S.M., a,b,S.V., Shivakumar Agarwal Kalmady Narayanaswamya,b,J.C., Venkatasubramaniana,b,G., Clinical Correlates of Parametric DigitSymbol Substitution Test in Schizophrenia, Asian Journal of Psychiatry (2014), http://dx.doi.org/10.1016/j.ajp.2014.03.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Original Research Title: Clinical Correlates of Parametric Digit-Symbol Substitution Test in Schizophrenia
ip t
Anekal C. Amaresha1,2, Vijay Danivas1,2, Venkataram Shivakumar1,2, Sri Mahavir Agarwal1,2, Sunil V. Kalmady1,2, Janardhanan C. Narayanaswamy1,2, Ganesan Venkatasubramanian1,2*
us
cr
¹Department of Psychiatry, National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore, India 2 Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Centre, National Institute of Mental Health & Neurosciences, Bangalore, India
*Corresponding author:
d te
Word count Abstract: 200 Manuscript Text: 2713 Tables: 2 Figures: 3
M
an
Dr. G. Venkatasubramanian MD, PhD Additional Professor of Psychiatry & Wellcome Trust / DBT India Alliance Senior Fellow Department of Psychiatry National Institute of Mental Health & Neurosciences (NIMHANS), Bangalore E-mail: [email protected] Phone: 080-26995256 Fax: 0091-80-26564830 / 26562121
Ac ce p
Acknowledgement: This research work is supported by the Wellcome Trust / DBT India Alliance Senior Fellowship Research Grant to GV. ACA, SVK & SMA are supported by Wellcome Trust / DBT India Alliance. VS is supported by the Indian Council of Medical Research. JCN is supported by the Department of Science & Technology, Government of India.
1 Page 1 of 20
Abstract Processing speed deficit, ascertained by Digit-Symbol Substitution Test (DSST), is considered as a
ip t
fundamental impairment in Schizophrenia. Clinical correlates of processing speed abnormalities, especially using the parametric version of DSST is yet to be evaluated comprehensively. In this
cr
study, we examined schizophrenia patients (N=66) and demographically-matched healthy controls
us
(N=72) using computer-administered parametric DSST (pDSST) with fixed (pDSSTF) as well as random (pDSSTR) conditions & analysed the relationship between pDSST performance and clinical
an
symptoms. Psychopathology was assessed using Scale for Assessment of Positive Symptoms (SAPS) / Negative Symptoms (SANS) with good inter-rater reliability. In comparison with healthy controls,
M
patients demonstrated significantly lesser number of correct responses (CN) in pDSSTF (t=8.0; p
