I ne tnaocnne society
number of fellows trained? By the number of scientific reports? By the number of patients cared for? Obviously, there are no simple answers. Rather, the answer lies in the marvelous ability to combine all three and to include compassion and sensitivity for one’s colleagues and patients along the way. Claude Migeon embodies these qualities along with those of the great researcher, teacher, and physician. He is an international scholar in the finest sense of the word, having attracted these and many other young endocrinologists from the world over to study with him at Hopkins. He is truly deserving of the Williams Award. Citation Clinical
for the Rhbe-Poulene Rorer Pharmaceutical Investigator Award of The Endocrine Society to Samuel S. C. Yen
Samuel S. C. Yen is currently a Professor of Reproductive Medicine at the University of California, San Diego, where for at least the last 20 yr he has added to our knowledge of the neuroendocrine regulation of the reproductive system, the endocrinology of the menstrual cycle, and the effects of reproductive hormones on metabolism. He has offered provocative theories on the genesisand/or treatment of polycystic ovary syndrome, premenstrual tension, menopause, hypothalamic causesof amenorrhea, pseudocyesis,and anorexia nervosa. He has studied feedback mechanismsas they relate to normal function and disease. Sam was born in Beijing, China, in 1927 and grew up during the Japaneseoccupation of China and the hostilities of World War II. He flew with the Flying Tigers asa teenager. His father was a physician who remained in China, but Sam entered the Medical School of the University of Hong Kong from which he graduated in 1954 followed by an internship in medicine at Queen Mary Hospital. He met Nicholson Eastman, Professor of Obstetrics from Johns Hopkins at this time in Hong Kong and obtained a coveted appointment to
Downloaded from https://academic.oup.com/mend/article-abstract/6/8/1352/2714752 by guest on 16 January 2019
Helping to galvanize the scientific community to defend the training grant programs, Claude becamea zealot on this issue and so many other public policy issuesaffecting academic science.In recognition of his many contributions in this area, he received the Ayerst Award from The Endocrine society in 1982. During his 40-yr career, Claude Migeon has contributed to the instruction of 65 American fellows and 37 fellows from abroad. Among them, 10 have been or are chairmen of pediatric departments, 3 are assistant or associatedeans of medical schools,and 5 are associatedwith major pharmaceutical companies. Almost all the others are directors of pediatric endocrine clinics and training programs in the United States, Europe, or South America. Thus, Claude’s influence on successivegenerations of pediatric endocrinologists has been profound and certainly worthy of the Williams Award. Claude’s contributions to the body of knowledge of steroid metabolism are legend. Since 1950 he has authored 350 scientific papers and numerous book chapters. Early in his careerhe studied the transplacental passageof steroids. Later, the establishment of the double isotope derivative methods allowed him to extend his studies to plasma androgens in man. Collaborating on these projects were Jean Bertrand, Carl Gemzell, Inese Beitins, Marco Rivarola, Jose Saez, Bernadette Loras, Maguelone Forest, and Roland Tremblay. In the sixties, Claude established the norms of adrenal function in infancy and childhood. Studies of cortisol secretion were carried out with Fritz Kenny, Paul Malvaux, Orville Green, Wellington Hung, and others. In 1970, with Francis Bayard, Inese Beitins, and Ave Kowarski, he published the first description of an RIA method for plasma and urinary aldosterone. Additional aldosterone studies with Bob Blizzard, Grant Liddle, Ave Kowarski, and Virginia Weldon showed that aldosterone secretion was increased in nonsalt-losing congenital adrenal hyperplasia. Additionally, his studies showed that although cortisol secretion is related to body size during growth and development, aldosterone secretion is constant from infancy to adulthood. With the help of Perrin White and in collaboration with Pat Donohoue, Neil Van Dop, Nick Jospe, and Romolo Sandrini, the Migeon-led group contributed to the study of the molecular basis of congenital adrenal hyperplasia. Because of Claude’s early involvement with this disorder, he along with John Rock, Georgeanna Klingensmith, Rose Mulaikal, and Maria Urban, was also able to report on the longterm follow-up of male and female patients. Another important contribution has been the study of androgen receptors in human skin fibroblasts and the investigation of the androgen insensitivity syndrome. Early studies were carried out with Bruce Keenan, Walter Meyer, Barbara Migeon, James Amrhein, Marc Maes, and Charles Sultan. Later the work of Terry Brown provided the molecular basis for the earlier research. Claude has had a long-standing interest in sex differentiation. Recently, he has participated with Gary Berkovitz, Patricia Fechner and collaborators in Peter Goodfellow’s laboratory investigating the role of the sex determining region of Y in testis determination. How does one measure such a remarkable career? By the
MOL 1354
END0
* 1992
reproductive system with elegant studies on neuroendocrine control of the cycle. This included an 11-yr period as chairman of the department. Roger Guillemin was at the Salk Institute in La Jolla at the time, and with his discovery of LH-releasing hormone a working collaboration with Sam evolved on the biological effects of LH-releasing hormone in patients. This was followed by studies with somatostatin and corticotropin-releasing hormone. Sam’s laboratory has also studied the effects of RU486 on the menstrual cycle and endometriosis. In 1978, Yen authored and edited with Bob Jaffe their classic text on reproductive endocrinology that has gone through its third successive edition by 199 1. An extraordinary number of fellows have worked in Sam’s laboratory and gone on to academic and research positions throughout the world. It is altogether fitting that he should be recognized by the Rorer award for his influential and pioneering work on the endocrinology of the reproductive system. Along with this award, Yen has been honored with numerous awards, lectureships, and services; among them are the Reproductive Biology Study Section, NIH; the National Advisory Council, NICHD; Member, Institute of Medicine, National Academy of Science, Society for Gynecological Investigation (past president), and the Johns Hopkins Society of Scholars. Also, Yen has been honored by the University of California San Diego as the first recipient of the Wallace R. Parsons Endowed Chair in Reproductive Endocrinology.
Downloaded from https://academic.oup.com/mend/article-abstract/6/8/1352/2714752 by guest on 16 January 2019
the Johns Hopkins obstetrical and gynecological residency from which he graduated in 1960. Sam next obtained a 2-yr fellowship as Chief of the Department of Obstetrics and Gynecology at the Guam Memorial Hospital, which qualified him to reenter the United States for citizenship. In his short tenure at Guam, he developed two interesting papers, one on the rupture of the liver during pregnancy and the other on the high incidence of diabetes and abnormal glucose tolerance during pregnancy in the native women of Guam. On reentering the United States in 1962, Sam migrated quickly from a fellowship at Harvard to a teaching post at the Case Western University Department of Obstetrics and Gynecology run by a friend from residency days, Kenneth J. Ryan. Under the tutelage of Olaf Pearson, Sam became interested in growth hormone and placental lactogen in pregnancy. For the next 10 yr there was a flow of studies from his laboratory on hormonal profiles during puberty and the menstrual cycle, studies of hormonal half-life in blood, the effects of clomiphene and wedge resection on polycystic ovary syndrome, and the effects of hormones on carbohydrate metabolism. All during this period he engaged in the practice and teaching of obstetrics and gynecology. In 1970, Sam moved to UCSD as a professor in a department that included Benirschke, Naftolin, Judd and Ryan. He quickly established himself as a true physiologist of the
Vol6-No8
number of fellows trained? By the number of scientific reports? By the number of patients cared for? Obviously, there are no simple answers. Rather, the answer lies in the marvelous ability to combine all three and to include compassion and sensitivity for one’s colleagues and patients along the way. Claude Migeon embodies these qualities along with those of the great researcher, teacher, and physician. He is an international scholar in the finest sense of the word, having attracted these and many other young endocrinologists from the world over to study with him at Hopkins. He is truly deserving of the Williams Award. Citation Clinical
for the Rhbe-Poulene Rorer Pharmaceutical Investigator Award of The Endocrine Society to Samuel S. C. Yen
Samuel S. C. Yen is currently a Professor of Reproductive Medicine at the University of California, San Diego, where for at least the last 20 yr he has added to our knowledge of the neuroendocrine regulation of the reproductive system, the endocrinology of the menstrual cycle, and the effects of reproductive hormones on metabolism. He has offered provocative theories on the genesisand/or treatment of polycystic ovary syndrome, premenstrual tension, menopause, hypothalamic causesof amenorrhea, pseudocyesis,and anorexia nervosa. He has studied feedback mechanismsas they relate to normal function and disease. Sam was born in Beijing, China, in 1927 and grew up during the Japaneseoccupation of China and the hostilities of World War II. He flew with the Flying Tigers asa teenager. His father was a physician who remained in China, but Sam entered the Medical School of the University of Hong Kong from which he graduated in 1954 followed by an internship in medicine at Queen Mary Hospital. He met Nicholson Eastman, Professor of Obstetrics from Johns Hopkins at this time in Hong Kong and obtained a coveted appointment to
Downloaded from https://academic.oup.com/mend/article-abstract/6/8/1352/2714752 by guest on 16 January 2019
Helping to galvanize the scientific community to defend the training grant programs, Claude becamea zealot on this issue and so many other public policy issuesaffecting academic science.In recognition of his many contributions in this area, he received the Ayerst Award from The Endocrine society in 1982. During his 40-yr career, Claude Migeon has contributed to the instruction of 65 American fellows and 37 fellows from abroad. Among them, 10 have been or are chairmen of pediatric departments, 3 are assistant or associatedeans of medical schools,and 5 are associatedwith major pharmaceutical companies. Almost all the others are directors of pediatric endocrine clinics and training programs in the United States, Europe, or South America. Thus, Claude’s influence on successivegenerations of pediatric endocrinologists has been profound and certainly worthy of the Williams Award. Claude’s contributions to the body of knowledge of steroid metabolism are legend. Since 1950 he has authored 350 scientific papers and numerous book chapters. Early in his careerhe studied the transplacental passageof steroids. Later, the establishment of the double isotope derivative methods allowed him to extend his studies to plasma androgens in man. Collaborating on these projects were Jean Bertrand, Carl Gemzell, Inese Beitins, Marco Rivarola, Jose Saez, Bernadette Loras, Maguelone Forest, and Roland Tremblay. In the sixties, Claude established the norms of adrenal function in infancy and childhood. Studies of cortisol secretion were carried out with Fritz Kenny, Paul Malvaux, Orville Green, Wellington Hung, and others. In 1970, with Francis Bayard, Inese Beitins, and Ave Kowarski, he published the first description of an RIA method for plasma and urinary aldosterone. Additional aldosterone studies with Bob Blizzard, Grant Liddle, Ave Kowarski, and Virginia Weldon showed that aldosterone secretion was increased in nonsalt-losing congenital adrenal hyperplasia. Additionally, his studies showed that although cortisol secretion is related to body size during growth and development, aldosterone secretion is constant from infancy to adulthood. With the help of Perrin White and in collaboration with Pat Donohoue, Neil Van Dop, Nick Jospe, and Romolo Sandrini, the Migeon-led group contributed to the study of the molecular basis of congenital adrenal hyperplasia. Because of Claude’s early involvement with this disorder, he along with John Rock, Georgeanna Klingensmith, Rose Mulaikal, and Maria Urban, was also able to report on the longterm follow-up of male and female patients. Another important contribution has been the study of androgen receptors in human skin fibroblasts and the investigation of the androgen insensitivity syndrome. Early studies were carried out with Bruce Keenan, Walter Meyer, Barbara Migeon, James Amrhein, Marc Maes, and Charles Sultan. Later the work of Terry Brown provided the molecular basis for the earlier research. Claude has had a long-standing interest in sex differentiation. Recently, he has participated with Gary Berkovitz, Patricia Fechner and collaborators in Peter Goodfellow’s laboratory investigating the role of the sex determining region of Y in testis determination. How does one measure such a remarkable career? By the
MOL 1354
END0
* 1992
reproductive system with elegant studies on neuroendocrine control of the cycle. This included an 11-yr period as chairman of the department. Roger Guillemin was at the Salk Institute in La Jolla at the time, and with his discovery of LH-releasing hormone a working collaboration with Sam evolved on the biological effects of LH-releasing hormone in patients. This was followed by studies with somatostatin and corticotropin-releasing hormone. Sam’s laboratory has also studied the effects of RU486 on the menstrual cycle and endometriosis. In 1978, Yen authored and edited with Bob Jaffe their classic text on reproductive endocrinology that has gone through its third successive edition by 199 1. An extraordinary number of fellows have worked in Sam’s laboratory and gone on to academic and research positions throughout the world. It is altogether fitting that he should be recognized by the Rorer award for his influential and pioneering work on the endocrinology of the reproductive system. Along with this award, Yen has been honored with numerous awards, lectureships, and services; among them are the Reproductive Biology Study Section, NIH; the National Advisory Council, NICHD; Member, Institute of Medicine, National Academy of Science, Society for Gynecological Investigation (past president), and the Johns Hopkins Society of Scholars. Also, Yen has been honored by the University of California San Diego as the first recipient of the Wallace R. Parsons Endowed Chair in Reproductive Endocrinology.
Downloaded from https://academic.oup.com/mend/article-abstract/6/8/1352/2714752 by guest on 16 January 2019
the Johns Hopkins obstetrical and gynecological residency from which he graduated in 1960. Sam next obtained a 2-yr fellowship as Chief of the Department of Obstetrics and Gynecology at the Guam Memorial Hospital, which qualified him to reenter the United States for citizenship. In his short tenure at Guam, he developed two interesting papers, one on the rupture of the liver during pregnancy and the other on the high incidence of diabetes and abnormal glucose tolerance during pregnancy in the native women of Guam. On reentering the United States in 1962, Sam migrated quickly from a fellowship at Harvard to a teaching post at the Case Western University Department of Obstetrics and Gynecology run by a friend from residency days, Kenneth J. Ryan. Under the tutelage of Olaf Pearson, Sam became interested in growth hormone and placental lactogen in pregnancy. For the next 10 yr there was a flow of studies from his laboratory on hormonal profiles during puberty and the menstrual cycle, studies of hormonal half-life in blood, the effects of clomiphene and wedge resection on polycystic ovary syndrome, and the effects of hormones on carbohydrate metabolism. All during this period he engaged in the practice and teaching of obstetrics and gynecology. In 1970, Sam moved to UCSD as a professor in a department that included Benirschke, Naftolin, Judd and Ryan. He quickly established himself as a true physiologist of the
Vol6-No8
