e u r o p e a n j o u r n a l o f p a e d i a t r i c n e u r o l o g y 1 8 ( 2 0 1 4 ) 3 0 1 e3 0 7

Official Journal of the European Paediatric Neurology Society

Original article

Chorioamnionitis and cerebral palsy: Lessons from a patient registry Allison Shevell a, Pia Wintermark b, Ruba Benini a, Michael Shevell a,b, Maryam Oskoui a,b,* a b

Department of Neurology & Neurosurgery, McGill University, Canada Department of Pediatrics, McGill University, Canada

article info

abstract

Article history:

Aim: The fetal neuroinflammatory response has been linked to the development of brain

Received 5 July 2013

injury in newborns and subsequent neurologic impairment. We aimed to explore the

Received in revised form

maternal and child factors associated with histologic chorioamnionitis in cerebral palsy.

19 December 2013

Methods: We conducted an observational study on a cohort of children with cerebral palsy

Accepted 20 December 2013

who were identified from the Quebec Cerebral Palsy Registry. Placental pathology was reported prospectively. Maternal and child factors associated with histological cho-

Keywords:

rioamnionitis were explored.

Placenta

Results: Placental reports were available in 455 of 534 (85%) children with cerebral palsy,

Chorioamnionitis

and of these 12% had histological signs of chorioamnionitis on reports. These children

Cerebral palsy

were more likely to have large placentas over 90th percentile for gestational age (53.7%

Periventricular white matter injury

versus 30.7%, p ¼ 0.001) and were born significantly more prematurely (