Accepted Article
Article Type: Original Article-Clinical Allergy
Children with atopic dermatitis show clinical improvement after Lactobacillus exposure I-Jen Wang1,2,3 and Jiu-Yao Wang4 1
Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan;
2
College of Medicine, National Yang-Ming University, Taipei, Taiwan;
3
China Medical University, Taichung, Taiwan;
4
Department of Pediatrics, College of Medicine, National Cheng Kung University, Taiwan
Short running title: probiotics and atopic dermatitis
Correspondence: Dr. I-Jen Wang Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, #127, Su-Yuan Road, Hsin-Chuang District, New Taipei City 242, Taiwan. Phone:
+886-2-2276-5566 ext. 2532
Fax:
+886-2-2998-8028
E-mail:
[email protected]
Summary Background The role of probiotics in the treatment of atopic dermatitis (AD) is not clearly established. Further clinical trials with new probiotic formulations are warranted. Objectives To assess the effects of Lactobacillus paracasei (LP) and Lactobacillus fermentum (LF),
and their mixture on the disease severity, quality of life, and immune biomarkers of children with AD.
Method A double-blind, prospective, randomized placebo-controlled study was conducted on 220 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cea.12489 This article is protected by copyright. All rights reserved.
Accepted Article
children aged 1-18 years with moderate-to-severe AD (Trial number: NCT01635738). The children were randomized to receive LP, LF, LP+LF mixture, and placebo for three months. Changes in SCORAD, FDLQI, and CDLQI scores in the different groups and at different visits were evaluated. Skin prick tests, levels of IgE, IFN-γ, IL-4, TGF-β, and TNF-α, and urine biomarkers were also evaluated. Results
Children who received LP, LF, and LP+LF mixture showed lower SCORAD scores than the
placebo group (p6 months, and with mite sensitization (p
Article Type: Original Article-Clinical Allergy
Children with atopic dermatitis show clinical improvement after Lactobacillus exposure I-Jen Wang1,2,3 and Jiu-Yao Wang4 1
Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, Taipei, Taiwan;
2
College of Medicine, National Yang-Ming University, Taipei, Taiwan;
3
China Medical University, Taichung, Taiwan;
4
Department of Pediatrics, College of Medicine, National Cheng Kung University, Taiwan
Short running title: probiotics and atopic dermatitis
Correspondence: Dr. I-Jen Wang Department of Pediatrics, Taipei Hospital, Ministry of Health and Welfare, #127, Su-Yuan Road, Hsin-Chuang District, New Taipei City 242, Taiwan. Phone:
+886-2-2276-5566 ext. 2532
Fax:
+886-2-2998-8028
E-mail:
[email protected]
Summary Background The role of probiotics in the treatment of atopic dermatitis (AD) is not clearly established. Further clinical trials with new probiotic formulations are warranted. Objectives To assess the effects of Lactobacillus paracasei (LP) and Lactobacillus fermentum (LF),
and their mixture on the disease severity, quality of life, and immune biomarkers of children with AD.
Method A double-blind, prospective, randomized placebo-controlled study was conducted on 220 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cea.12489 This article is protected by copyright. All rights reserved.
Accepted Article
children aged 1-18 years with moderate-to-severe AD (Trial number: NCT01635738). The children were randomized to receive LP, LF, LP+LF mixture, and placebo for three months. Changes in SCORAD, FDLQI, and CDLQI scores in the different groups and at different visits were evaluated. Skin prick tests, levels of IgE, IFN-γ, IL-4, TGF-β, and TNF-α, and urine biomarkers were also evaluated. Results
Children who received LP, LF, and LP+LF mixture showed lower SCORAD scores than the
placebo group (p6 months, and with mite sensitization (p
