Accepted Date : 12-Feb-2015 Article type
: Original Article
Title: Characterization of hospital and community acquired respiratory syncytial virus in children with severe lower respiratory tract infections in Ho Chi Minh City, Vietnam, 2010
Running title: Hospital and community acquired RSV, Vietnam
Tran Anh Tuana#, Tran Tan Thanhb#, Nguyen thi Thanh Haia, Le Binh Bao Tinha, Le thi Ngoc Kima, Lien Anh Ha Dob, Nguyen thi Thuy Chinh B’Krongb, Nguyen thi Thamb, Vu thi Ty Hangb, Laura Mersonb, Jeremy Farrarb,c,d, Tang Chi Thuonga, Menno D de Jonge, Constance Schultszf and H Rogier van Doornb,c* a: Children’s Hospital 1, 341 Su Van Hanh, Q10, Ho Chi Minh City, Vietnam b: Oxford University Clinical Research Unit in partnership with the Hospital for Tropical Diseases, 746 Vo Van Kiet, Q5, Ho Chi Minh City, Vietnam c: Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK d: Current affiliation: Wellcome trust of Great Britain, London, UK e: Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands f: Department of Global Health-Amsterdam Institute of Global Health and Development, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands #: Contributed equally *: Corresponding author
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/irv.12307 This article is protected by copyright. All rights reserved.
Email addresses: Tran Tan Thanh: [email protected], Tran Anh Tuan: [email protected], Nguyen thi Thanh Hai: [email protected], Le Binh Bao Tinh: [email protected], Le thi Ngoc Kim: [email protected], Lien Anh Ha Do: [email protected], Nguyen thi Thuy Chinh B’Krong: [email protected], Nguyen thi Tham: [email protected], Vu thi Ty Hang: [email protected], Laura Merson: [email protected], Jeremy Farrar: [email protected], Tang Chi Thuong: [email protected], Menno D de Jong: [email protected], Constance Schultsz: [email protected], H Rogier van Doorn: [email protected].
Abstract Background: Human respiratory syncytial virus (RSV) is an important community and nosocomial pathogen in developed countries but data regarding the importance of RSV in developing countries are relatively scarce.
Methods: During a one-year surveillance study in 2010 we took serial samples from children admitted to the Emergency Unit of the Respiratory Ward of Children’s Hospital 1 in Ho Chi Minh City, Vietnam. RSV was detected within 72h of admission to the ward in 26 % (376/1439; RSV A: n=320; RSV B: n=54, and RSV A and B: n=2). Among those negative in the first 72h after admission, 6.6% (25/377) acquired nosocomial RSV infection during hospitalization (RSV A: n=22; and RSV B: n=3).
Results: Children with nosocomial RSV infection were younger (P=0.001) and had a longer duration of hospitalization (p
: Original Article
Title: Characterization of hospital and community acquired respiratory syncytial virus in children with severe lower respiratory tract infections in Ho Chi Minh City, Vietnam, 2010
Running title: Hospital and community acquired RSV, Vietnam
Tran Anh Tuana#, Tran Tan Thanhb#, Nguyen thi Thanh Haia, Le Binh Bao Tinha, Le thi Ngoc Kima, Lien Anh Ha Dob, Nguyen thi Thuy Chinh B’Krongb, Nguyen thi Thamb, Vu thi Ty Hangb, Laura Mersonb, Jeremy Farrarb,c,d, Tang Chi Thuonga, Menno D de Jonge, Constance Schultszf and H Rogier van Doornb,c* a: Children’s Hospital 1, 341 Su Van Hanh, Q10, Ho Chi Minh City, Vietnam b: Oxford University Clinical Research Unit in partnership with the Hospital for Tropical Diseases, 746 Vo Van Kiet, Q5, Ho Chi Minh City, Vietnam c: Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK d: Current affiliation: Wellcome trust of Great Britain, London, UK e: Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands f: Department of Global Health-Amsterdam Institute of Global Health and Development, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands #: Contributed equally *: Corresponding author
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/irv.12307 This article is protected by copyright. All rights reserved.
Email addresses: Tran Tan Thanh: [email protected], Tran Anh Tuan: [email protected], Nguyen thi Thanh Hai: [email protected], Le Binh Bao Tinh: [email protected], Le thi Ngoc Kim: [email protected], Lien Anh Ha Do: [email protected], Nguyen thi Thuy Chinh B’Krong: [email protected], Nguyen thi Tham: [email protected], Vu thi Ty Hang: [email protected], Laura Merson: [email protected], Jeremy Farrar: [email protected], Tang Chi Thuong: [email protected], Menno D de Jong: [email protected], Constance Schultsz: [email protected], H Rogier van Doorn: [email protected].
Abstract Background: Human respiratory syncytial virus (RSV) is an important community and nosocomial pathogen in developed countries but data regarding the importance of RSV in developing countries are relatively scarce.
Methods: During a one-year surveillance study in 2010 we took serial samples from children admitted to the Emergency Unit of the Respiratory Ward of Children’s Hospital 1 in Ho Chi Minh City, Vietnam. RSV was detected within 72h of admission to the ward in 26 % (376/1439; RSV A: n=320; RSV B: n=54, and RSV A and B: n=2). Among those negative in the first 72h after admission, 6.6% (25/377) acquired nosocomial RSV infection during hospitalization (RSV A: n=22; and RSV B: n=3).
Results: Children with nosocomial RSV infection were younger (P=0.001) and had a longer duration of hospitalization (p
