Medicine
®
Observational Study
OPEN
Characteristics of infection and its impact on short-term outcome in patients with acute-on-chronic liver failure ∗
Junjun Cai, PhDa, Mengchen Zhang, MSa, Tao Han, MD, PhDb, , Hui-qing Jiang, MD, PhDa,
∗
Abstract
Bacterial infections are an important cause of mortality in liver failure. However, the type of infection, predictors of infection, and their impact on outcomes in patients with acute-on-chronic liver failure (ACLF) are limited. A total of 389 patients with ACLF were admitted in this retrospective, corhort study. Once admitted, clinical data including first infection site, type (community-acquired, healthcare-associated, or nosocomial), and second infection occurrence during hospitalization were collected. The outcome was mortality within 90 days. Multivariable logistic regression models were preformed to predict second infection development and 90-day mortality. Survival probability curves were calculated by the Kaplan–Meier method. Among 389 patients, 316 (81.2%) patients had infection. The 90-day mortality of patients with and without infection was 52.2% and 16.4%, respectively (P
®
Observational Study
OPEN
Characteristics of infection and its impact on short-term outcome in patients with acute-on-chronic liver failure ∗
Junjun Cai, PhDa, Mengchen Zhang, MSa, Tao Han, MD, PhDb, , Hui-qing Jiang, MD, PhDa,
∗
Abstract
Bacterial infections are an important cause of mortality in liver failure. However, the type of infection, predictors of infection, and their impact on outcomes in patients with acute-on-chronic liver failure (ACLF) are limited. A total of 389 patients with ACLF were admitted in this retrospective, corhort study. Once admitted, clinical data including first infection site, type (community-acquired, healthcare-associated, or nosocomial), and second infection occurrence during hospitalization were collected. The outcome was mortality within 90 days. Multivariable logistic regression models were preformed to predict second infection development and 90-day mortality. Survival probability curves were calculated by the Kaplan–Meier method. Among 389 patients, 316 (81.2%) patients had infection. The 90-day mortality of patients with and without infection was 52.2% and 16.4%, respectively (P
