HHS Public Access Author manuscript Author Manuscript
Drug Alcohol Depend. Author manuscript; available in PMC 2017 June 01. Published in final edited form as: Drug Alcohol Depend. 2016 June 1; 163: 157–164. doi:10.1016/j.drugalcdep.2016.04.006.
Cessation of Alcohol Consumption Decreases Rate of Nicotine Metabolism In Male Alcohol-Dependent Smokers# Noah R. Gubner1, Aleksandra Kozar-Konieczna2, Izabela Szoltysek-Boldys3, Ewa SlodczykMankowska3, Jerzy Goniewicz2, Andrzej Sobczak3,4, Peyton Jacob III1, Neal L. Benowitz1,5, and Maciej L. Goniewicz6,* Maciej L. Goniewicz: [email protected]
Author Manuscript
1Center
for Tobacco Control Research and Education, University of California, San Francisco, CA, USA of Addiction Treatment, Parzymiechy, Poland 3Department of General and Inorganic Chemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland 4Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland 5Clinical Pharmacology and Experimental Therapeutics, Departments of Medicine and Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA 6Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, NY, USA 2Center
Abstract
Author Manuscript
Background—Rate of nicotine metabolism is an important factor influencing cigarette smoking behavior, dependence, and efficacy of nicotine replacement therapy. The current study examined the hypothesis that chronic alcohol abuse can accelerate the rate of nicotine metabolism. Nicotine metabolite ratio (NMR, a biomarker for rate of nicotine metabolism) and patterns of nicotine metabolites were assessed at three time points after alcohol cessation. Methods—Participants were 22 Caucasian men randomly selected from a sample of 165 smokers entering a 7-week alcohol dependence treatment program in Poland. Data were collected at three time points: baseline (week 1, after acute alcohol detoxification), week 4, and week 7. Urine was analyzed for nicotine and metabolites and used to determine the nicotine metabolite ratio (NMR, a biomarker for rate of nicotine metabolism), and total nicotine equivalents (TNE, a biomarker for total daily nicotine exposure).
Author Manuscript
Results and conclusions—There was a significant decrease in urine NMR over the 7 weeks after alcohol abstinence (F(2,42)=18.83, p
Drug Alcohol Depend. Author manuscript; available in PMC 2017 June 01. Published in final edited form as: Drug Alcohol Depend. 2016 June 1; 163: 157–164. doi:10.1016/j.drugalcdep.2016.04.006.
Cessation of Alcohol Consumption Decreases Rate of Nicotine Metabolism In Male Alcohol-Dependent Smokers# Noah R. Gubner1, Aleksandra Kozar-Konieczna2, Izabela Szoltysek-Boldys3, Ewa SlodczykMankowska3, Jerzy Goniewicz2, Andrzej Sobczak3,4, Peyton Jacob III1, Neal L. Benowitz1,5, and Maciej L. Goniewicz6,* Maciej L. Goniewicz: [email protected]
Author Manuscript
1Center
for Tobacco Control Research and Education, University of California, San Francisco, CA, USA of Addiction Treatment, Parzymiechy, Poland 3Department of General and Inorganic Chemistry, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland 4Institute of Occupational Medicine and Environmental Health, Sosnowiec, Poland 5Clinical Pharmacology and Experimental Therapeutics, Departments of Medicine and Bioengineering & Therapeutic Sciences, University of California, San Francisco, CA, USA 6Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, NY, USA 2Center
Abstract
Author Manuscript
Background—Rate of nicotine metabolism is an important factor influencing cigarette smoking behavior, dependence, and efficacy of nicotine replacement therapy. The current study examined the hypothesis that chronic alcohol abuse can accelerate the rate of nicotine metabolism. Nicotine metabolite ratio (NMR, a biomarker for rate of nicotine metabolism) and patterns of nicotine metabolites were assessed at three time points after alcohol cessation. Methods—Participants were 22 Caucasian men randomly selected from a sample of 165 smokers entering a 7-week alcohol dependence treatment program in Poland. Data were collected at three time points: baseline (week 1, after acute alcohol detoxification), week 4, and week 7. Urine was analyzed for nicotine and metabolites and used to determine the nicotine metabolite ratio (NMR, a biomarker for rate of nicotine metabolism), and total nicotine equivalents (TNE, a biomarker for total daily nicotine exposure).
Author Manuscript
Results and conclusions—There was a significant decrease in urine NMR over the 7 weeks after alcohol abstinence (F(2,42)=18.83, p
