4. Voiculescu V, Alexianu M, Popescu-Tismana G, et al. Polyneuropathy with lipid deposits in Schwann cells and axonal degeneranon in cerebrotendinous xanthomatosis. J Neurol Sci 1987;82:
89-99 5. Salen G, Shefer S, Berginer VM. Familial diseases with storage of sterols other than cholesterol: cerebrotendinous xanthomatosis and sitosterolemia with xanrhomatosis. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, et al, eds. The basis of inherited disease, ed 5. New York: McGraw Hill, 1983:713-738
*Department of Nezlrology Hospital 2Elx
Cerebrospinal Fluid Taurine GI Alzheimer’s Disease
Un&wPty of Alacant
J. Alom,* J. N. Mahy,? N. Brandi,? and E. Tolosat
The article by Kowall and Beal [l}describes how glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer’s Disease (AD). Although glutamate 123,among other neurotransmitters E31, has been involved in the neurochemical degenerative process in AD, less is known about taurine. Their interesting report suggests that taurine-containing neurons could also be involved in this pathological process. We would like to communicate our results about recent measurements of cerebrospinal fluid (CSF) taurine, among other amino acids, in the same group of A D patients in which we previously found CSF neuropeptide Y decrements [4]. Twenty consecutive patients (7 men and 13 women with a mean age of 64.4 yr, range 52-75 yr) were entered in the study. All met the diagnostic criteria for probable AD according to the NINCDS-ADRDA Work Group. Symptomatic causes of dementia were excluded by laboratory examination, electroencephalography, and computed tomography. All patiencs included in the study had a Hachinski ischemic score of
89-99 5. Salen G, Shefer S, Berginer VM. Familial diseases with storage of sterols other than cholesterol: cerebrotendinous xanthomatosis and sitosterolemia with xanrhomatosis. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, et al, eds. The basis of inherited disease, ed 5. New York: McGraw Hill, 1983:713-738
*Department of Nezlrology Hospital 2Elx
Cerebrospinal Fluid Taurine GI Alzheimer’s Disease
Un&wPty of Alacant
J. Alom,* J. N. Mahy,? N. Brandi,? and E. Tolosat
The article by Kowall and Beal [l}describes how glutamate-, glutaminase-, and taurine-immunoreactive neurons develop neurofibrillary tangles in Alzheimer’s Disease (AD). Although glutamate 123,among other neurotransmitters E31, has been involved in the neurochemical degenerative process in AD, less is known about taurine. Their interesting report suggests that taurine-containing neurons could also be involved in this pathological process. We would like to communicate our results about recent measurements of cerebrospinal fluid (CSF) taurine, among other amino acids, in the same group of A D patients in which we previously found CSF neuropeptide Y decrements [4]. Twenty consecutive patients (7 men and 13 women with a mean age of 64.4 yr, range 52-75 yr) were entered in the study. All met the diagnostic criteria for probable AD according to the NINCDS-ADRDA Work Group. Symptomatic causes of dementia were excluded by laboratory examination, electroencephalography, and computed tomography. All patiencs included in the study had a Hachinski ischemic score of
