Accepted Manuscript Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease André Karch, Peter Hermann, Claudia Ponto, Matthias Schmitz, Amandeep Arora, Saima Zafar, Franc Llorens, Annika Müller-Heine, Inga Zerr PII:
S0197-4580(15)00070-6
DOI:
10.1016/j.neurobiolaging.2015.01.021
Reference:
NBA 9202
To appear in:
Neurobiology of Aging
Received Date: 19 October 2014 Revised Date:
8 January 2015
Accepted Date: 30 January 2015
Please cite this article as: Karch, A., Hermann, P., Ponto, C., Schmitz, M., Arora, A., Zafar, S., Llorens, F., Müller-Heine, A., Zerr, I., Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease, Neurobiology of Aging (2015), doi: 10.1016/ j.neurobiolaging.2015.01.021. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT 1
Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic
2
Creutzfeldt-Jakob disease
3 1,2,3
4
André Karch
5
Peter Hermann
6
Claudia Ponto
7
Matthias Schmitz
8
Amandeep Arora
9
Saima Zafar
2
[email protected]
2
[email protected] 2,4
[email protected]
2
[email protected]
2
2,4
11
Annika Müller-Heine
12
Inga Zerr
[email protected] 5
[email protected]
M AN U
Franc Llorens
SC
[email protected]
10
2,4
[email protected]
13 14
1
15
Infection Research, 38124 Braunschweig, Germany
16
2
17
37075 Göttingen, Germany
18
3
19
Germany
20
4
21
5
Epidemiological and Statistical Methods (ESME), Department of Epidemiology, Helmholtz Centre for
TE D
National Reference Center for TSE, Clinical Dementia Center, University Medical School Göttingen,
EP
German Center for Infection Research (DZIF), Hannover-Braunschweig site, 30625 Hannover
German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany Institute of Biostatistics, Hannover Medical School (MHH), 30625 Hannover, Germany
AC C
22
RI PT
[email protected]
23
Corresponding author:
24
Dr. André Karch
25
Department of Epidemiology
26
Helmholtz Centre for Infection Research
27
Inhoffenstr. 7
28
38124 Braunschweig, Germany
29
Tel.: +49 531 6181 3113
30
Email: [email protected]
1
ACCEPTED MANUSCRIPT Abstract:
32
The molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic
33
marker for patient survival. However, subtype determination is not possible during life-time. Since the
34
rate of disease progression is associated with the molecular subtype, this study aimed at investigating
35
if total tau, a marker of neuronal death, allows pre-mortem diagnosis of molecular subtype when
36
codon 129 genotype is known.
37
296 sCJD patients were tested for their cerebrospinal fluid total tau level at time of diagnosis and were
38
investigated for their sCJD subtype post-mortem.
39
There was a significant association between tau levels and the prion protein type in patients with
40
codon 129 MM (p
S0197-4580(15)00070-6
DOI:
10.1016/j.neurobiolaging.2015.01.021
Reference:
NBA 9202
To appear in:
Neurobiology of Aging
Received Date: 19 October 2014 Revised Date:
8 January 2015
Accepted Date: 30 January 2015
Please cite this article as: Karch, A., Hermann, P., Ponto, C., Schmitz, M., Arora, A., Zafar, S., Llorens, F., Müller-Heine, A., Zerr, I., Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt-Jakob disease, Neurobiology of Aging (2015), doi: 10.1016/ j.neurobiolaging.2015.01.021. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT 1
Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic
2
Creutzfeldt-Jakob disease
3 1,2,3
4
André Karch
5
Peter Hermann
6
Claudia Ponto
7
Matthias Schmitz
8
Amandeep Arora
9
Saima Zafar
2
[email protected]
2
[email protected] 2,4
[email protected]
2
[email protected]
2
2,4
11
Annika Müller-Heine
12
Inga Zerr
[email protected] 5
[email protected]
M AN U
Franc Llorens
SC
[email protected]
10
2,4
[email protected]
13 14
1
15
Infection Research, 38124 Braunschweig, Germany
16
2
17
37075 Göttingen, Germany
18
3
19
Germany
20
4
21
5
Epidemiological and Statistical Methods (ESME), Department of Epidemiology, Helmholtz Centre for
TE D
National Reference Center for TSE, Clinical Dementia Center, University Medical School Göttingen,
EP
German Center for Infection Research (DZIF), Hannover-Braunschweig site, 30625 Hannover
German Center for Neurodegenerative Diseases (DZNE), 37075 Göttingen, Germany Institute of Biostatistics, Hannover Medical School (MHH), 30625 Hannover, Germany
AC C
22
RI PT
[email protected]
23
Corresponding author:
24
Dr. André Karch
25
Department of Epidemiology
26
Helmholtz Centre for Infection Research
27
Inhoffenstr. 7
28
38124 Braunschweig, Germany
29
Tel.: +49 531 6181 3113
30
Email: [email protected]
1
ACCEPTED MANUSCRIPT Abstract:
32
The molecular subtype of sporadic Creutzfeldt-Jakob disease (sCJD) is an important prognostic
33
marker for patient survival. However, subtype determination is not possible during life-time. Since the
34
rate of disease progression is associated with the molecular subtype, this study aimed at investigating
35
if total tau, a marker of neuronal death, allows pre-mortem diagnosis of molecular subtype when
36
codon 129 genotype is known.
37
296 sCJD patients were tested for their cerebrospinal fluid total tau level at time of diagnosis and were
38
investigated for their sCJD subtype post-mortem.
39
There was a significant association between tau levels and the prion protein type in patients with
40
codon 129 MM (p
