Accepted Manuscript Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke Guo-Ju Sun, Su-Chun Ding, Wen-Yuan Ling, Fang Wang, Xiao-Ping Yang PII:
S1878-8750(15)00754-8
DOI:
10.1016/j.wneu.2015.06.006
Reference:
WNEU 2958
To appear in:
World Neurosurgery
Received Date: 3 March 2015 Revised Date:
3 June 2015
Accepted Date: 4 June 2015
Please cite this article as: Sun G-J, Ding S-C, Ling W-Y, Wang F, Yang X-P, Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke, World Neurosurgery (2015), doi: 10.1016/j.wneu.2015.06.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Title page Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke Guo-Ju Sun1 , Su-Chun Ding2 , Wen-Yuan Ling3, Fang Wang4, Xiao-Ping Yang5 ※
※
＃
RI PT
1. Department of Anesthesiology, Weihai Hospital of Medical College of Qingdao University, Weihai, P. R. China
2. Department of Anesthesiology, Yantai Yuhuangding Hospital of Medical College of Qingdao
SC
University, Yantai, P. R. China
3. Department of Neurosurgery, the Affiliated Hospital of Weifang Medical University, Weifang, P.
M AN U
R. China
4. Affiliated Yantai Hospital of Binzhou Medical University, Yantai, P. R. China 5. School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, 264003, P. R. China ＃
Corresponding author: Xiao-Ping Yang; E-mail: [email protected]; TEL: 86-0535-6913016
Address: No. 346, Guanhai Road, Yantai, 264003, Shandong province, P. R. China These authors contributed equally to this study.
TE D
※
Articles type： ：Original Article
EP
Word count: 3014
AC C
Running title： ：CSF FFA Are Associated with Stroke Subtypes and Severity
1
ACCEPTED MANUSCRIPT Abbreviations CSF= cerebrospinal fluid FFA=Free fatty acid AIS=acute ischemic stroke
CE=cardioembolic AF=atrial fibrillation DWI= diffusion-weighted imaging Hs-CRP= high sensitivity C-reactive protein
IQR= interquartile ranges ROC = Receiver operating characteristic
AC C
EP
TE D
AUC= Area under the curve
M AN U
CV= coefficient of variation
SC
RI PT
NIHSS=National Institutes of Health Stroke Scale
2
ACCEPTED MANUSCRIPT Abstract Background： The aim of this study was to assess the clinical significance of cerebrospinal fluid (CSF) free fatty acid (FFA) levels in Chinese patients with acute ischemic stroke (AIS).
RI PT
Methods: From December 2011 to October 2014, all patients with first-ever AIS were recruited to participate in the study. CSF levels of FFA were assayed at 4 various time points and severity of
SC
stroke and was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score upon admission.
M AN U
Results:
The results indicated that the median CSF FFA levels were significantly (P
S1878-8750(15)00754-8
DOI:
10.1016/j.wneu.2015.06.006
Reference:
WNEU 2958
To appear in:
World Neurosurgery
Received Date: 3 March 2015 Revised Date:
3 June 2015
Accepted Date: 4 June 2015
Please cite this article as: Sun G-J, Ding S-C, Ling W-Y, Wang F, Yang X-P, Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke, World Neurosurgery (2015), doi: 10.1016/j.wneu.2015.06.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT
Title page Cerebrospinal Fluid Free Fatty Acid Levels Are Associated with Stroke Subtypes and Severity in Chinese Patients with Acute Ischemic Stroke Guo-Ju Sun1 , Su-Chun Ding2 , Wen-Yuan Ling3, Fang Wang4, Xiao-Ping Yang5 ※
※
＃
RI PT
1. Department of Anesthesiology, Weihai Hospital of Medical College of Qingdao University, Weihai, P. R. China
2. Department of Anesthesiology, Yantai Yuhuangding Hospital of Medical College of Qingdao
SC
University, Yantai, P. R. China
3. Department of Neurosurgery, the Affiliated Hospital of Weifang Medical University, Weifang, P.
M AN U
R. China
4. Affiliated Yantai Hospital of Binzhou Medical University, Yantai, P. R. China 5. School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, 264003, P. R. China ＃
Corresponding author: Xiao-Ping Yang; E-mail: [email protected]; TEL: 86-0535-6913016
Address: No. 346, Guanhai Road, Yantai, 264003, Shandong province, P. R. China These authors contributed equally to this study.
TE D
※
Articles type： ：Original Article
EP
Word count: 3014
AC C
Running title： ：CSF FFA Are Associated with Stroke Subtypes and Severity
1
ACCEPTED MANUSCRIPT Abbreviations CSF= cerebrospinal fluid FFA=Free fatty acid AIS=acute ischemic stroke
CE=cardioembolic AF=atrial fibrillation DWI= diffusion-weighted imaging Hs-CRP= high sensitivity C-reactive protein
IQR= interquartile ranges ROC = Receiver operating characteristic
AC C
EP
TE D
AUC= Area under the curve
M AN U
CV= coefficient of variation
SC
RI PT
NIHSS=National Institutes of Health Stroke Scale
2
ACCEPTED MANUSCRIPT Abstract Background： The aim of this study was to assess the clinical significance of cerebrospinal fluid (CSF) free fatty acid (FFA) levels in Chinese patients with acute ischemic stroke (AIS).
RI PT
Methods: From December 2011 to October 2014, all patients with first-ever AIS were recruited to participate in the study. CSF levels of FFA were assayed at 4 various time points and severity of
SC
stroke and was evaluated with the National Institutes of Health Stroke Scale (NIHSS) score upon admission.
M AN U
Results:
The results indicated that the median CSF FFA levels were significantly (P
