Eur. Neurol. 14: 129-137 (1976)

Cerebrospinal Fluid Concentration of Cyclic AMP in Cerebrovascular Diseases E. R. H eikkinen, V. V. M yllyla, E. H okkanen and H. V apaatalo Departments of Pharmacology and Neurology, University of Oulu, Oulu, and Institute of Biomedical Sciences, University of Tampere, Tampere

Key Words. Cyclic AMP ■Enzymes • Cerebrospinal fluid • Cerebrovascular dis­ eases • Hypertension Abstract. Concentration of cyclic adenosine 3',5'-monophosphate (cAMP) and activities of some enzymes were measured in cerebrospinal fluid (CSF) from 38 pa­ tients with various cerebrovascular diseases. Cerebral infarction of the carotid area ( 2 months)

24.1 ±2.7 (3)

9.0 (1)

_

6.1 ±2.1 (2)

13.5 ±9.6 (2)

Intracerebral hemorrhage

29.3 ±5.9 (3)

8.1 ±0.9 (2)

6.2 ±1.3 (2)

10.7 ±7.4 (2)

17.5 ±0.5 (2)

Subarachnoid hemorrhage

24.4 ±9.7 (3)

10.3 ±0.7 (3)

2.6±0.6 (2)

14.8±0.9 (3)** 144.7 ± 113.6 (3)

Transient ischemic attack (T1A)

21.3 ±1.5 (15)

10.6 ±1.1 (8)

2.3 ±0.5 (7)

7.2 ±1.8 (8)

Syncope

18.9±4.0 (4)

8.5 ±1.5 (2)

4.0 ±2.0 (2)

6.6 ±0.0 (2)

CK

LDH

14.1 ±1.6 (8) 7.0 (1)

Means ±SE. The number of the patients is indicated in brackets. * pcO.OOl when compared to the value of patients in TIA group; ** p