Cells to Surgery Quiz
Cells to Surgery Quiz: November 2014 Mohammad-Ali Yazdani Abyaneh1, Robert D. Griffith1, Leyre Falto-Aizpurua1 and Keyvan Nouri1 Journal of Investigative Dermatology (2014) 134, e7. doi:10.1038/jid.2014.395
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. Which of the following experimental observations has led to the study of mesenchymal stem cells (MSCs) for preventing the lesion above?
a. MSCs are activated by proinflammatory mediators. b. MSCs inhibit proinflammatory mediators. c. MSCs modulate all three phases of wound healing. d. MSCs have been safely applied to human cutaneous wounds. e. All of the above.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. Injection of MSCs into cutaneous wounds in animal models has been shown to cause which of the following? a. Increased macrophage secretion of TNF-α. b. Delayed wound closure. c. Decreased TGF-β1:TGF-β3 ratio. d. Increased myofibroblast differentiation. e. All of the above.
3. Liu et al. demonstrated that MSCs generate their therapeutic effects in hypertrophic scar prevention a. After inciting immunologic rejection by the host. b. Through long-term engraftment in tissue. c. Through upregulation of profibrotic mediators. d. While undergoing rapid and extensive apoptosis. e. By promoting inflammatory cell infiltration into the wound area.
TOPIC ARTICLES The questions refer to the following articles: Liu S, Jiang L, Li H et al. (2014) Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. J Invest Dermatol 134:2648–2657 Qi Y, Jiang D, Sindrilaru A et al. (2014) TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds. J Invest Dermatol 134:526–37
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.395.
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Cells to Surgery Quiz: November 2014 Mohammad-Ali Yazdani Abyaneh1, Robert D. Griffith1, Leyre Falto-Aizpurua1 and Keyvan Nouri1 Journal of Investigative Dermatology (2014) 134, e7. doi:10.1038/jid.2014.395
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. Which of the following experimental observations has led to the study of mesenchymal stem cells (MSCs) for preventing the lesion above?
a. MSCs are activated by proinflammatory mediators. b. MSCs inhibit proinflammatory mediators. c. MSCs modulate all three phases of wound healing. d. MSCs have been safely applied to human cutaneous wounds. e. All of the above.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. Injection of MSCs into cutaneous wounds in animal models has been shown to cause which of the following? a. Increased macrophage secretion of TNF-α. b. Delayed wound closure. c. Decreased TGF-β1:TGF-β3 ratio. d. Increased myofibroblast differentiation. e. All of the above.
3. Liu et al. demonstrated that MSCs generate their therapeutic effects in hypertrophic scar prevention a. After inciting immunologic rejection by the host. b. Through long-term engraftment in tissue. c. Through upregulation of profibrotic mediators. d. While undergoing rapid and extensive apoptosis. e. By promoting inflammatory cell infiltration into the wound area.
TOPIC ARTICLES The questions refer to the following articles: Liu S, Jiang L, Li H et al. (2014) Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. J Invest Dermatol 134:2648–2657 Qi Y, Jiang D, Sindrilaru A et al. (2014) TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds. J Invest Dermatol 134:526–37
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.395.
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
