Cells to Surgery Quiz
Cells to Surgery Quiz: May 2015 Fleta N. Bray1, Mohammed Alsaidan1, Leyre Falto-Aizpurua1, Brian J. Simmons1, Mohammad-Ali Yazdani Abyaneh1, Robert D. Griffith1 and Keyvan Nouri1 Journal of Investigative Dermatology (2015) 135, e13. doi:10.1038/jid.2015.101
Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from the National Pressure Ulcer Advisory Panel
QUESTIONS 1. An 87-year-old man with past medical history of stroke is a resident of a long-term care facility. Staff members have been conservatively managing his sacral pressure ulcer. What is the stage of the ulcer according to the National Pressure Ulcer Advisory Panel staging system? a. Stage I. b. Stage II. c. Stage III. d. Stage IV.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
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1
Journal of Investigative Dermatology (2015), Volume 135
© 2015 The Society for Investigative Dermatology
Cells to Surgery Quiz
2. Kruppel-like factor 4 (KLF4) is a transcription factor that has been experimentally shown to promote wound healing through which of the following mechanisms? a. KLF4 promotes the migration of keratinocytes across the open wound. b. KLF4 regulates the wound-healing process by modulating TGF-β1 signaling. c. KLF4 regulates the recruitment of myeloid-derived suppressor cells and their subsequent differentiation into fibrocytes. d. KLF4 is involved in the transition from basal to suprabasal keratinocyte phenotype and facilitates reepithelialization at the wound front.
3. Conservative management results in limited improvement of the patient’s sacral pressure ulcer, and a surgical approach is planned. You decide to create a flap. Which of the following is the most common source of flaps for sacral pressure ulcers? a. Rectus femoris flap. b. Vastus lateralis flap. c. Lumbosacral flap. d. Gluteal flap.
TOPIC ARTICLE The questions refer to the following article: Ou L, Shi Y, Dong W et al. (2015) Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells. J Invest Dermatol 135:1425–34
Answers are available as supplementary material online. http://dx.doi.org/10.1038/jid.2015.101.
2
Journal of Investigative Dermatology (2015), Volume 135
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Cells to Surgery Quiz: May 2015 Fleta N. Bray1, Mohammed Alsaidan1, Leyre Falto-Aizpurua1, Brian J. Simmons1, Mohammad-Ali Yazdani Abyaneh1, Robert D. Griffith1 and Keyvan Nouri1 Journal of Investigative Dermatology (2015) 135, e13. doi:10.1038/jid.2015.101
Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from the National Pressure Ulcer Advisory Panel
QUESTIONS 1. An 87-year-old man with past medical history of stroke is a resident of a long-term care facility. Staff members have been conservatively managing his sacral pressure ulcer. What is the stage of the ulcer according to the National Pressure Ulcer Advisory Panel staging system? a. Stage I. b. Stage II. c. Stage III. d. Stage IV.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
1
Journal of Investigative Dermatology (2015), Volume 135
© 2015 The Society for Investigative Dermatology
Cells to Surgery Quiz
2. Kruppel-like factor 4 (KLF4) is a transcription factor that has been experimentally shown to promote wound healing through which of the following mechanisms? a. KLF4 promotes the migration of keratinocytes across the open wound. b. KLF4 regulates the wound-healing process by modulating TGF-β1 signaling. c. KLF4 regulates the recruitment of myeloid-derived suppressor cells and their subsequent differentiation into fibrocytes. d. KLF4 is involved in the transition from basal to suprabasal keratinocyte phenotype and facilitates reepithelialization at the wound front.
3. Conservative management results in limited improvement of the patient’s sacral pressure ulcer, and a surgical approach is planned. You decide to create a flap. Which of the following is the most common source of flaps for sacral pressure ulcers? a. Rectus femoris flap. b. Vastus lateralis flap. c. Lumbosacral flap. d. Gluteal flap.
TOPIC ARTICLE The questions refer to the following article: Ou L, Shi Y, Dong W et al. (2015) Kruppel-like factor KLF4 facilitates cutaneous wound healing by promoting fibrocyte generation from myeloid-derived suppressor cells. J Invest Dermatol 135:1425–34
Answers are available as supplementary material online. http://dx.doi.org/10.1038/jid.2015.101.
2
Journal of Investigative Dermatology (2015), Volume 135
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
