Cells to Surgery Quiz
Cells to Surgery Quiz: March 2015 Fleta N. Bray1, Brian J. Simmons1, Robert D. Griffith1, Leyre Falto-Aizpurua1, Mohammad-Ali Yazdani Abyaneh1 and Keyvan Nouri1 Journal of Investigative Dermatology (2015) 135, e11. doi:10.1038/jid.2014.543
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
Questions 1. A mother brings her 3-year-old daughter to your office with concerns over a slowly enlarging “birthmark” present on the left buttock. What is your diagnosis? a. Café-au-lait macule. b. Congenital melanocytic nevus. c. Epidermal nevus. d. Dermal melanocytosis (“Mongolian spot”).
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2015 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. When compared with superficial spreading melanoma (SSM), large lesions (>20 cm in diameter) of the above have been experimentally shown to do which of the following? a. Stain negative for the melanoma markers MITF and HMB45. b. Have significantly greater numbers of the neural crest stem cell markers Sox10 and Nestin. c. Harbor more MITF+ cells and fewer Sox10+ cells, reflecting a higher ratio of differentiated cells. d. Have similar levels of chemoresistance mediator ABCD5+ cells. e. Have greater Ki67 expression, reflecting greater proliferative activity of melanocytes.
3. You discuss management options with the mother of the child. For patients with large lesions (>20 cm in diameter) who undergo surgical excision, it is important to educate the patient regarding which of the following? a. Risk of malignant transformation. b. Need for lifelong surveillance. c. Potential for lesion recurrence. d. All of the above.
TOPIC ARTICLE The questions refer to the following article: Charbel C, Fontaine RH, Kadlub N et al. (2015) Clonogenic cell subpopulations maintain congenital melanocytic nevi. J Invest Dermatol 135:824–33
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.543.
2
Journal of Investigative Dermatology (2015), Volume 135
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Cells to Surgery Quiz: March 2015 Fleta N. Bray1, Brian J. Simmons1, Robert D. Griffith1, Leyre Falto-Aizpurua1, Mohammad-Ali Yazdani Abyaneh1 and Keyvan Nouri1 Journal of Investigative Dermatology (2015) 135, e11. doi:10.1038/jid.2014.543
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
Questions 1. A mother brings her 3-year-old daughter to your office with concerns over a slowly enlarging “birthmark” present on the left buttock. What is your diagnosis? a. Café-au-lait macule. b. Congenital melanocytic nevus. c. Epidermal nevus. d. Dermal melanocytosis (“Mongolian spot”).
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2015 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. When compared with superficial spreading melanoma (SSM), large lesions (>20 cm in diameter) of the above have been experimentally shown to do which of the following? a. Stain negative for the melanoma markers MITF and HMB45. b. Have significantly greater numbers of the neural crest stem cell markers Sox10 and Nestin. c. Harbor more MITF+ cells and fewer Sox10+ cells, reflecting a higher ratio of differentiated cells. d. Have similar levels of chemoresistance mediator ABCD5+ cells. e. Have greater Ki67 expression, reflecting greater proliferative activity of melanocytes.
3. You discuss management options with the mother of the child. For patients with large lesions (>20 cm in diameter) who undergo surgical excision, it is important to educate the patient regarding which of the following? a. Risk of malignant transformation. b. Need for lifelong surveillance. c. Potential for lesion recurrence. d. All of the above.
TOPIC ARTICLE The questions refer to the following article: Charbel C, Fontaine RH, Kadlub N et al. (2015) Clonogenic cell subpopulations maintain congenital melanocytic nevi. J Invest Dermatol 135:824–33
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.543.
2
Journal of Investigative Dermatology (2015), Volume 135
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
