Cells to Surgery Quiz
Cells to Surgery Quiz: June 2014 Robert D. Griffith1, Mohammad-Ali Yazdani Abyaneh1, Leyre Falto-Aizpurua1 and Keyvan Nouri1 Journal of Investigative Dermatology (2014) 134, e2. doi:10.1038/jid.2014.184
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. A 54-year-old white man presents with the lesion shown above on his left lower arm and a similar-appearing lesion on his left upper back. There is no regional lymphadenopathy, and he is otherwise asymptomatic. Histopathologic and immuno histochemical analyses of the lesion shown are consistent with a primary melanoma with a thickness of 2.40 mm. The lesion on the patient’s back reveals findings concerning for a possible metastatic melanoma to the skin with a thickness of 3.20 mm. Which of the following is a tumor-produced extracellular matrix protein that could help distinguish a metastatic melanoma to the skin from a second primary melanoma and guide further workup for this patient?
a. Capsase 3. b. Cyclin-dependent kinase 2 (CDK-2). c. Cyclin-dependent kinase 6 (CDK-6). d. Phospholipase A2. e. Transforming growth factor-β–inducible (TGFBI) protein.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. A drug company is interested in developing an antibody against the protein that was used to distinguish metastatic melanoma to the skin from a second primary melanoma in the hope of controlling outgrowth of metastases. Which of the following phases of the cell cycle is most likely to be affected by this drug? a. G1. b. G1/S transition. c. G2. d. M phase. e. G0.
3. The appropriate steps in management were undertaken. Four months later, the patient complained of frequent headaches, and he was found to have metastases to the brain and left lung. The patient underwent cytotoxic treatment with a serine/threonine kinase BRAF inhibitor. Three months after treatment was started, the metastatic lesions in the brain and left lung have grown significantly. You suspect this may be due to a case of rapid repopulation of tumor cells that can occur after cytotoxic therapy. A drug that targets which of the following proteins might have helped to prevent this complication? a. Arachidonic acid. b. Caspase 3. c. Cyclin-dependent kinase 2 (CDK-2). d. Cyclin-dependent kinase 6 (CDK-6). e. Phospholipase A2.
TOPIC ARTICLES Questions 1 to 3 refer to the following articles: Donato AL, Huang Q, Liu X et al. (2014) Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. J Invest Dermatol 134:1686–92 Lauden L, Siewiera J, Boukouaci W et al. (2014) TGF-β-induced (TGFBI) protein in melanoma: a signature of high metastatic potential. J Invest Dermatol 134:1675–85
Answers are available as supplementary material at http:dx.doi.org/10.1038/jid.2014.184.
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
Cells to Surgery Quiz: June 2014 Robert D. Griffith1, Mohammad-Ali Yazdani Abyaneh1, Leyre Falto-Aizpurua1 and Keyvan Nouri1 Journal of Investigative Dermatology (2014) 134, e2. doi:10.1038/jid.2014.184
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. A 54-year-old white man presents with the lesion shown above on his left lower arm and a similar-appearing lesion on his left upper back. There is no regional lymphadenopathy, and he is otherwise asymptomatic. Histopathologic and immuno histochemical analyses of the lesion shown are consistent with a primary melanoma with a thickness of 2.40 mm. The lesion on the patient’s back reveals findings concerning for a possible metastatic melanoma to the skin with a thickness of 3.20 mm. Which of the following is a tumor-produced extracellular matrix protein that could help distinguish a metastatic melanoma to the skin from a second primary melanoma and guide further workup for this patient?
a. Capsase 3. b. Cyclin-dependent kinase 2 (CDK-2). c. Cyclin-dependent kinase 6 (CDK-6). d. Phospholipase A2. e. Transforming growth factor-β–inducible (TGFBI) protein.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2014 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. A drug company is interested in developing an antibody against the protein that was used to distinguish metastatic melanoma to the skin from a second primary melanoma in the hope of controlling outgrowth of metastases. Which of the following phases of the cell cycle is most likely to be affected by this drug? a. G1. b. G1/S transition. c. G2. d. M phase. e. G0.
3. The appropriate steps in management were undertaken. Four months later, the patient complained of frequent headaches, and he was found to have metastases to the brain and left lung. The patient underwent cytotoxic treatment with a serine/threonine kinase BRAF inhibitor. Three months after treatment was started, the metastatic lesions in the brain and left lung have grown significantly. You suspect this may be due to a case of rapid repopulation of tumor cells that can occur after cytotoxic therapy. A drug that targets which of the following proteins might have helped to prevent this complication? a. Arachidonic acid. b. Caspase 3. c. Cyclin-dependent kinase 2 (CDK-2). d. Cyclin-dependent kinase 6 (CDK-6). e. Phospholipase A2.
TOPIC ARTICLES Questions 1 to 3 refer to the following articles: Donato AL, Huang Q, Liu X et al. (2014) Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. J Invest Dermatol 134:1686–92 Lauden L, Siewiera J, Boukouaci W et al. (2014) TGF-β-induced (TGFBI) protein in melanoma: a signature of high metastatic potential. J Invest Dermatol 134:1675–85
Answers are available as supplementary material at http:dx.doi.org/10.1038/jid.2014.184.
2
Journal of Investigative Dermatology (2014), Volume 134
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
