Cells to Surgery Quiz
Cells to Surgery Quiz: February 2015 Brian J. Simmons1, Robert D. Griffith1, Leyre Falto-Aizpurua1, Mohammad-Ali Yazdani Abyaneh1 and Keyvan Nouri1 Journal of Investigative Dermatology (2015) 135, e10. doi:10.1038/jid.2014.497
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
Questions 1. A 65-year-old Caucasian man presents with the lesion pictured above, which he says has been growing for several years. The patient has a history of long-term exposure to the sun, poor compliance with the application of sunscreen, and multiple episodes of blistering sunburns as a child. Dermoscopy shows “atypical red vessels, arborizing vessels and featureless areas.” What is the most likely diagnosis? a. Sebaceous hyperplasia. b. Molluscum contagiosum. c. Nodular basal cell carcinoma. d. Keratoacanthoma.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2015 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. Sierra et al. used reflectance confocal microscopy (RCM) to observe the skin changes before and after Er:YAG laser ablation in tumor specimens with an intact stratum corneum to mimic in vivo conditions. When RCM images of treated specimens were compared to histopathology, they found a potentially high __________. a. Positive predictive value. b. Negative predictive value. c. False-positive rate. d. False-negative rate. 3. What was determined to be the limiting factor of reflectance confocal microscopy in allowing detection of residual tumor after laser ablation? a. Image tumor-to-dermis resolution. b. Image tumor-to-dermis contrast. c. Both of the above.
TOPIC ARTICLE The questions refer to the following article: Sierra H, Cordova M, Chen C-SJ et al. (2015) Confocal imaging–guided laser ablation of basal cell carcinomas: an ex vivo study. J Invest Dermatol 135:612–15
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.497.
2
Journal of Investigative Dermatology (2015), Volume 135
Cells to Surgery Quiz: February 2015 Brian J. Simmons1, Robert D. Griffith1, Leyre Falto-Aizpurua1, Mohammad-Ali Yazdani Abyaneh1 and Keyvan Nouri1 Journal of Investigative Dermatology (2015) 135, e10. doi:10.1038/jid.2014.497
JID and Logical Images, Inc., have cooperated to offer the Cells to Surgery Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
Questions 1. A 65-year-old Caucasian man presents with the lesion pictured above, which he says has been growing for several years. The patient has a history of long-term exposure to the sun, poor compliance with the application of sunscreen, and multiple episodes of blistering sunburns as a child. Dermoscopy shows “atypical red vessels, arborizing vessels and featureless areas.” What is the most likely diagnosis? a. Sebaceous hyperplasia. b. Molluscum contagiosum. c. Nodular basal cell carcinoma. d. Keratoacanthoma.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
© 2015 The Society for Investigative Dermatology
www.jidonline.org
1
Cells to Surgery Quiz
2. Sierra et al. used reflectance confocal microscopy (RCM) to observe the skin changes before and after Er:YAG laser ablation in tumor specimens with an intact stratum corneum to mimic in vivo conditions. When RCM images of treated specimens were compared to histopathology, they found a potentially high __________. a. Positive predictive value. b. Negative predictive value. c. False-positive rate. d. False-negative rate. 3. What was determined to be the limiting factor of reflectance confocal microscopy in allowing detection of residual tumor after laser ablation? a. Image tumor-to-dermis resolution. b. Image tumor-to-dermis contrast. c. Both of the above.
TOPIC ARTICLE The questions refer to the following article: Sierra H, Cordova M, Chen C-SJ et al. (2015) Confocal imaging–guided laser ablation of basal cell carcinomas: an ex vivo study. J Invest Dermatol 135:612–15
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2014.497.
2
Journal of Investigative Dermatology (2015), Volume 135
