Cell Line: 2004–2014 First Resource

First Theory article

Cell gets a new look: Leading Edge is born

PaperFlicks: authors on camera

Cell tweets

Lady Gaga parody goes viral – “I want good data. A paper in Cell.”

MicroRNA biology Bartel Vol. 116, 281–297

Voices shares scientific perspectives

Cell joins Facebook nation Genome editing in a nonhuman primate

Pluripotent SCs from human fibroblasts Yamanaka Vol. 131, 861–872

"This paper proposed the notion that immune ignorance to the microbiota, the prevailing theory at the time, may not hold true in all cases."

Carbon dating the brain Frisén Vol. 122, 133–143

2005

NF-κB links inflammation and cancer

2006

Tishkoff Vol. 150, 457–469

2007 High-resolution view on DNA methylation

2008 PaperClips debut

2009

2010

Defining supplementary material

2011

2013

Rapid genome editing in mice

Jaenisch Vol. 154, 1370–1379

2014

Beige adipocytes

Cell Picture Show celebrates beauty in science

Spiegelman Vol. 150, 366–376

Mouse cortical connectomics

Tetherin ligates HIV

Dong Vol. 156, 1096–1111

Hallmarks of Cancer for a new decade

Bieniasz Vol. 139, 499–511

Chen Vol. 122, 669–682

2012

Human somatic cell nuclear transfer Mitalipov Vol. 153, 1228–1238

Evolutionary history from whole-genome sequences of hunter-gatherers

Discovery of MAVS

Karin Vol. 118, 285–296

Hanahan and Weinberg Vol. 144, 646–674

Histone demethylase Shi Vol. 119, 941–953 AC

"The inability to see global demethylation by LSD1… demonstrates the gene specific nature of demethylation...."

RORγT master of Th17 cells

Cua and Littman Vol. 126, 1121–1133 AC

lncRNAs in HOX regulation

Rinn and Chang Vol. 129, 1311–1323 AC

"Peter Campbell and colleagues made a truly remarkable observation noting cancer genomes in which DNA rearrangements occurred in a highly focal manner - with many DNA rearrangements basically arising on a single chromosome."

Computational model for an entire cell Personal 'omics'

Snyder Vol. 148, 1293–1307

Covert Vol. 150, 389–401

cGAMP generation and immune function Base-resolution sequencing of 5hmC Ren Vol. 149, 1368–1380

Patel Vol. 153, 1094–1107 Vol. 154, 748–762

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OF EXCIT

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40 SI

NCE 1974

B I O LOGY

"Another surprising result: the first demonstration that a long noncoding RNA can act in trans to regulate a chromatin domain."

Stratton, Futreal, and Campbell Vol. 144, 27–40 AC

NG

“…the claim that Th17 cells were a distinct population met with much skepticism…. [T]hat an orphan nuclear receptor RoRγt was the transcription factor required for the differentiation of Th17 cells from that common progenitor resolved that controversy.”

Chromothripsis

D

Zhao Vol. 132, 887–898

U R DE CA

ChIP-seq for hi-res nucleosome positioning

Nobel Prize

McKnight Vol. 149, 753–767 Vol. 149, 768–779

"The finding that iPSCs could also be derived from adult tail tip fibroblasts nailed this story."

Jacobsen and Ecker Vol. 126, 1189–1201

LEGEND

RNA granules as hydrogels

Settleman Vol. 141, 69–80

Takahashi and Yamanaka Vol. 126, 663–676 AC

Open archive

Landmark Paper Essential Review Cell Milestone Publishing Innovation AC Annotated Classic

Cancer cells sample drug-tolerant state

Wagers and Lee Vol. 153, 828–839

FO

2004

Articles enhanced!

Four factors reprogram mouse fibroblasts

Medzhitov Vol. 118, 229–241 AC

Circulating factor reverses cardiac aging phenotype

Alt and Dekker Vol. 148, 908–921

SnapShot Microbiota maintains host homeostasis

Sha Vol. 156, 836–843

Spatial organization of the mouse genome

Cell line: 2004-2014.

2014 marks Cell's 40th anniversary, and over the year we have looked back at how discoveries of the last four decades have molded our understanding of...
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