Microbiol. Immunol. Vol. 36 (3), 317-320, 1992

Depressed CD4/CD8 Ratio in TPHA-Negative Patients with Syphilis TSugiyasu

KANDA,*,1

Tadashi SUZUKI,1

Hiroshi

and

SHINOHARA,2

Kazuhiko

MURATA1

1Gunma UniversitySchoolof Medicine, Maebashi, Gunma 371, Japan, and 2ShinoharaHospital , Kiryu, Gunma 376, Japan (Accepted for publication, December 1, 1991)

Abstract

The

used

method

(age

72.4+8.3 (RPR)

positive.

lower

was

than

also

(1.08 •}

in vs.

excluding

vs.

CD4

1.07, elderly

%,

We

0.05).

because

data

+

that

that

with suggest

of

142 the

that

widely elderly

negative.

Their

TPHA-

the

numbers

both were vs.

ratio

significantly

1,064+ of

the

were

with

CD4

TPHA-positive

immunological

a six

(FTA-ABS)

compared

found

(722

compared These

was

syphilitics

and

is with

tests

were

TPHA-negative

syphilitics

syphilitics

TPHA

treponemal syphilis

P

CD8 ratio in TPHA-negative patients with syphilis.

The Treponema pallidum hemagglutination assay (TPHA) is a widely used method for screening syphilis. We report our experience with six elderly (age 72...
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