ORIGINAL RESEARCH
Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis Rene Baudrand, MD; Nidhi Gupta, PhD; Amanda E. Garza, PhD; Anand Vaidya, MD; Jane A. Leopold, MD; Paul N. Hopkins, MD; Xavier Jeunemaitre, MD; Claudio Ferri, MD; Jose R. Romero, PhD; Jonathan Williams, MD; Joseph Loscalzo, MD, PhD; Gail K. Adler, MD, PhD; Gordon H. Williams, MD; Luminita H. Pojoga, PhD
Background-—Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav-1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav-1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav-1–null mice and humans with a prevalent variant in the CAV1 gene. Methods and Results-—In mouse studies, cav-1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high- to low-density lipoprotein (all P
Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis Rene Baudrand, MD; Nidhi Gupta, PhD; Amanda E. Garza, PhD; Anand Vaidya, MD; Jane A. Leopold, MD; Paul N. Hopkins, MD; Xavier Jeunemaitre, MD; Claudio Ferri, MD; Jose R. Romero, PhD; Jonathan Williams, MD; Joseph Loscalzo, MD, PhD; Gail K. Adler, MD, PhD; Gordon H. Williams, MD; Luminita H. Pojoga, PhD
Background-—Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav-1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav-1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav-1–null mice and humans with a prevalent variant in the CAV1 gene. Methods and Results-—In mouse studies, cav-1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high- to low-density lipoprotein (all P
