BIOMEDICAL REPORTS 2: 915-917
Cathepsin K in treatment monitoring following intravenous zoledronic acid OLIVER JAHN1, THOMAS WEX2,3, SILKE KLOSE4, SIEGFRIED KROPF5, DANIELA ADOLF5 and STEFAN PIATEK1 1
Department of Trauma Surgery; 2Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, D‑39120 Magdeburg; 3Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department Molecular Genetics, Otto von Guericke University, D‑39124 Magdeburg; 4Department of Nephrology, Hypertension, Endocrinology and Metabolic Diseases; 5 Department of Biometry and Medical Informatics, Otto von Guericke University, D‑39120 Magdeburg, Germany Received July 23, 2014; Accepted August 27, 2014 DOI: 10.3892/br.2014.360 Abstract. Cathepsin K (CatK) is mainly expressed by osteoclasts and plays an important role in bone resorption. As CatK is expressed and secreted by osteoclasts during active bone resorption, it may be a useful and specific biochemical marker of osteoclastic activity. Therefore, CatK serum levels were studied for monitoring the treatment of females with postmenopausal osteoporosis by zoledronic acid. The serum CatK levels were determined in nine postmenopausal females before and after 3, 6 and 12 months of treatment. The levels were significantly reduced after 3 and 6 months (P
Cathepsin K in treatment monitoring following intravenous zoledronic acid OLIVER JAHN1, THOMAS WEX2,3, SILKE KLOSE4, SIEGFRIED KROPF5, DANIELA ADOLF5 and STEFAN PIATEK1 1
Department of Trauma Surgery; 2Department of Gastroenterology, Hepatology and Infectious Diseases, Otto von Guericke University, D‑39120 Magdeburg; 3Medical Laboratory for Clinical Chemistry, Microbiology and Infectious Diseases, Department Molecular Genetics, Otto von Guericke University, D‑39124 Magdeburg; 4Department of Nephrology, Hypertension, Endocrinology and Metabolic Diseases; 5 Department of Biometry and Medical Informatics, Otto von Guericke University, D‑39120 Magdeburg, Germany Received July 23, 2014; Accepted August 27, 2014 DOI: 10.3892/br.2014.360 Abstract. Cathepsin K (CatK) is mainly expressed by osteoclasts and plays an important role in bone resorption. As CatK is expressed and secreted by osteoclasts during active bone resorption, it may be a useful and specific biochemical marker of osteoclastic activity. Therefore, CatK serum levels were studied for monitoring the treatment of females with postmenopausal osteoporosis by zoledronic acid. The serum CatK levels were determined in nine postmenopausal females before and after 3, 6 and 12 months of treatment. The levels were significantly reduced after 3 and 6 months (P
