'."
Br. J. Pharmacol. (1992), 107, 262-268
Macmillan Press
Ltd, 1992
Cardiovascular effects of substituted tetrahydroisoquinolines in rats Hui Dong, 'Chi-Ming Lee, *Wen-Long Huang & *Si-Xun Peng Chinese Medicinal Material Research Centre and Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong and *Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China 1 A series of substituted tetrahydroisoquinolines derived from the cleavage products of tetrandrine were found to inhibit [3H]-nitrendipine binding to rat cerebral cortical membranes. Those compounds which displaced [3H]-nitrendipine binding were also able to inhibit high KC1-induced contraction of rat aorta in vitro. 2 There was a significant correlation between the ability of these tetrahydroisoquinolines to inhibit [3H]-nitrendipine binding and KCl-induced contraction (r = 0.99, P
Br. J. Pharmacol. (1992), 107, 262-268
Macmillan Press
Ltd, 1992
Cardiovascular effects of substituted tetrahydroisoquinolines in rats Hui Dong, 'Chi-Ming Lee, *Wen-Long Huang & *Si-Xun Peng Chinese Medicinal Material Research Centre and Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong and *Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China 1 A series of substituted tetrahydroisoquinolines derived from the cleavage products of tetrandrine were found to inhibit [3H]-nitrendipine binding to rat cerebral cortical membranes. Those compounds which displaced [3H]-nitrendipine binding were also able to inhibit high KC1-induced contraction of rat aorta in vitro. 2 There was a significant correlation between the ability of these tetrahydroisoquinolines to inhibit [3H]-nitrendipine binding and KCl-induced contraction (r = 0.99, P
