756 mean concentration of aluminium in the heart muscle in this study is greater than that found in normal skeletal muscle by Alfrey et al.,7 and the three high values are in the range found for patients on renal dialysis taking aluminium-hydroxide gel daily. There was no evidence that any of the subjects in our study had been taking such high doses of aluminium antacids. Since aluminium is one of the few elements which are often found in higher concentration in softer waters, the possibility of a toxic effect of aluminium in ischaemic heart-disease probably deserves further
ischaemic heart-disease.1 56 The
investigation. Department of Biochemistry, University of Hull, Hull HU6 7RX
BARBARA CHIPPERFIELD
Department of Chemistry, University of Hull
J. R. CHIPPERFIELD N. R. BOWER
CARCINOEMBRYONIC ANTIGEN REVISITED as a specific tumour antigen, whose might be helpful in the diagnosis of cancer, carcinoembryonic antigen (C.E.A.) has sunk into disfavour because of reports of limited sensitivity and specificity. A specific role for c.E.A. as a biological marker of neoplasms of the digestive tract, especially large-bowel tumours, and the possibility of monitoring response to surgery and chemotherapy have been claimed by our groupl2 and others.3 We studied 330 patients, examined in the medical oncology outpatient service of the Ospedale S. Carlo Borromeo and
SIR,-First acclaimed
detection in
serum
cordance between
C.E.A.
pattern and response to chemotherapy
(table). Medical
Oncology, Ospedale S. Carlo Borromeo and Policlinico
Milan, Italy Istituto
Sieroterapico Milanese "S. Belfanti"
G. LUPORINI P. FRASCHINI R. LABIANCA F. MANGIAROTTI
CLASSICAL HÆMOPHILIA IN GIRL WITH 46,XX KARYOTYPE AND NO FAMILY HISTORY OF BLEEDING DISORDER
SIR,-Classical haemophilia (factor-viu deficiency) is a bleeding disorder that is usually seen in males and is inherited as a sex-linked recessive trait. The disorder has been reported in females in several families with male haemophiliacs. Female haemophiliacs without such a family history have been described,’-3 but their separation from von Willebrand’s disease (another disorder associated with the functional deficiency of factor VIII) was not always clear. The plasma level of factor-vin-like antigen4and platelet aggregation by ristocetin’ can now distinguish classical haemophilia from von Wille-
CORRELATION BETWEEN RESPONSE TO CHEMOTHERAPY AND C.E.A. LEVELS IN
68
PATIENTS WITH ADVANCED
LARGE-BOWEL NEOPLASMS
&khgr;2=21 (P
ischaemic heart-disease.1 56 The
investigation. Department of Biochemistry, University of Hull, Hull HU6 7RX
BARBARA CHIPPERFIELD
Department of Chemistry, University of Hull
J. R. CHIPPERFIELD N. R. BOWER
CARCINOEMBRYONIC ANTIGEN REVISITED as a specific tumour antigen, whose might be helpful in the diagnosis of cancer, carcinoembryonic antigen (C.E.A.) has sunk into disfavour because of reports of limited sensitivity and specificity. A specific role for c.E.A. as a biological marker of neoplasms of the digestive tract, especially large-bowel tumours, and the possibility of monitoring response to surgery and chemotherapy have been claimed by our groupl2 and others.3 We studied 330 patients, examined in the medical oncology outpatient service of the Ospedale S. Carlo Borromeo and
SIR,-First acclaimed
detection in
serum
cordance between
C.E.A.
pattern and response to chemotherapy
(table). Medical
Oncology, Ospedale S. Carlo Borromeo and Policlinico
Milan, Italy Istituto
Sieroterapico Milanese "S. Belfanti"
G. LUPORINI P. FRASCHINI R. LABIANCA F. MANGIAROTTI
CLASSICAL HÆMOPHILIA IN GIRL WITH 46,XX KARYOTYPE AND NO FAMILY HISTORY OF BLEEDING DISORDER
SIR,-Classical haemophilia (factor-viu deficiency) is a bleeding disorder that is usually seen in males and is inherited as a sex-linked recessive trait. The disorder has been reported in females in several families with male haemophiliacs. Female haemophiliacs without such a family history have been described,’-3 but their separation from von Willebrand’s disease (another disorder associated with the functional deficiency of factor VIII) was not always clear. The plasma level of factor-vin-like antigen4and platelet aggregation by ristocetin’ can now distinguish classical haemophilia from von Wille-
CORRELATION BETWEEN RESPONSE TO CHEMOTHERAPY AND C.E.A. LEVELS IN
68
PATIENTS WITH ADVANCED
LARGE-BOWEL NEOPLASMS
&khgr;2=21 (P
