Molecular Vision 2014; 20:200-214 Received 23 February 2013 | Accepted 28 February 2014 | Published 3 March 2014
© 2014 Molecular Vision
Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes Xiufen Yang,1,2 Yu Deng,1,3 Hong Gu,1 Xuetao Ren,1,4 Na Li,1 Apiradee Lim,5 Torkel Snellingen,4 Xipu Liu,4 Ningli Wang,1 Ningpu Liu1 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China; 2Department of Ophthalmology, the Friendship Hospital, Capital Medical University, Beijing, China; 3Department of Ophthalmology, Fu Xing Hospital, Capital Medical University, Beijing, China; 4Sekwa Institute of Vision Science, Beijing, China; 5Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani, Thailand 1
Purpose: To investigate whether variants in a set of eight candidate genes are associated with diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). Methods: Case-control study. Patients with T2DM were recruited from the Desheng community in urban Beijing and assigned into a DR group or diabetic without retinopathy (DWR) group, based on the duration of diabetes and grading of fundus images. Twenty-six single-nucleotide polymorphisms (SNPs) within eight candidate genes, including PPARγ, vascular endothelial growth factor (VEGF) and its receptor kinase insert domain receptor (KDR), erythropoietin, aldose reductase, protein kinase C-β, angiotensin-converting enzyme, and intercellular adhesion molecule 1, were analyzed using the MassARRAY genotyping system. Results: A total of 500 patients with T2DM (216 with DR and 284 with DWR) were enrolled in the study. Significant associations of DR were noted with genotypes of four SNPs—rs699947 (p
© 2014 Molecular Vision
Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes Xiufen Yang,1,2 Yu Deng,1,3 Hong Gu,1 Xuetao Ren,1,4 Na Li,1 Apiradee Lim,5 Torkel Snellingen,4 Xipu Liu,4 Ningli Wang,1 Ningpu Liu1 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China; 2Department of Ophthalmology, the Friendship Hospital, Capital Medical University, Beijing, China; 3Department of Ophthalmology, Fu Xing Hospital, Capital Medical University, Beijing, China; 4Sekwa Institute of Vision Science, Beijing, China; 5Department of Mathematics and Computer Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani, Thailand 1
Purpose: To investigate whether variants in a set of eight candidate genes are associated with diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). Methods: Case-control study. Patients with T2DM were recruited from the Desheng community in urban Beijing and assigned into a DR group or diabetic without retinopathy (DWR) group, based on the duration of diabetes and grading of fundus images. Twenty-six single-nucleotide polymorphisms (SNPs) within eight candidate genes, including PPARγ, vascular endothelial growth factor (VEGF) and its receptor kinase insert domain receptor (KDR), erythropoietin, aldose reductase, protein kinase C-β, angiotensin-converting enzyme, and intercellular adhesion molecule 1, were analyzed using the MassARRAY genotyping system. Results: A total of 500 patients with T2DM (216 with DR and 284 with DWR) were enrolled in the study. Significant associations of DR were noted with genotypes of four SNPs—rs699947 (p
